Wretlind B, Pavlovskis O R
Scand J Infect Dis Suppl. 1981;29:13-9.
Most Pseudomonas aeruginosa strains produce exotoxin A and two extracellular proteases (elastase and alkaline protease). Exotoxin A is a lethal toxin that inhibits protein synthesis in mammalian cells by the same mechanism as diphtheria toxin. It is generated in clinical and experimental animal infections. Passive or active immunization against this toxin gives significant protection against experimental infections with exotoxin-producing strains. The proteases have tissue-damaging activity and are capable of degrading various plasma proteins such as complement and coagulation factors. Proteases probably play a part in localized pseudomonas infections such as keratitis, pneumonia and burn infection. When invasion and colonization have occurred and septicemia is established, these enzymes probably are less important.
大多数铜绿假单胞菌菌株会产生外毒素A和两种细胞外蛋白酶（弹性蛋白酶和碱性蛋白酶）。外毒素A是一种致死性毒素，其通过与白喉毒素相同的机制抑制哺乳动物细胞中的蛋白质合成。它在临床和实验性动物感染中产生。针对这种毒素的被动或主动免疫可提供针对产外毒素菌株实验性感染的显著保护。这些蛋白酶具有组织损伤活性，能够降解各种血浆蛋白，如补体和凝血因子。蛋白酶可能在局部铜绿假单胞菌感染（如角膜炎、肺炎和烧伤感染）中起作用。当发生侵袭和定植并确立败血症时，这些酶可能就不那么重要了。
