Andersen P K
Acta Anaesthesiol Scand. 1981 Aug;25(4):344-8. doi: 10.1111/j.1399-6576.1981.tb01664.x.
The effects of varying ventilations (VE) and fresh gas flows (FGF) on end-expiratory CO2 (FECO2) levels were investigated in an experimental model lung, employing the Hafnia modification of the Mapleson A and D anaesthetic systems during CO2-absorption and CO2-wash-out (rebreathing). Identical results were found in both systems: FECO2 was constant and independent of FGF with CO2-absorption and constant VE, whereas rebreathing resulted in increasing FECO2 levels as FGF was decreased. As control of FECO2 in the rebreathing systems by regulating FGF could only take place within FECO2 levels higher than that determined by VE at complete CO2-absorption, e.g. for the Hafnia A and D rebreathing systems, control of FGF necessitates relative hyperventilation. FECO2 with constant FGF decreased with increasing VE during CO2-absorption, as well as during rebreathing, although this decrease was less in the rebreathing systems. Thus a decrease in FECO2 with rising VE can be avoided and hypocapnia prevented. The results agree with those obtained in clinical studies.
在一个实验模型肺中,采用Mapleson A和D麻醉系统的哈夫尼亚改良版,在二氧化碳吸收和二氧化碳排出(再呼吸)过程中,研究了不同通气量(VE)和新鲜气体流量(FGF)对呼气末二氧化碳(FECO2)水平的影响。在两个系统中发现了相同的结果:在二氧化碳吸收和恒定的VE条件下,FECO2是恒定的,且与FGF无关,而在再呼吸过程中,随着FGF的降低,FECO2水平会升高。由于在再呼吸系统中通过调节FGF来控制FECO2只能在高于完全二氧化碳吸收时由VE所确定的FECO2水平内进行,例如对于哈夫尼亚A和D再呼吸系统,控制FGF需要相对过度通气。在二氧化碳吸收期间以及再呼吸期间,在恒定FGF条件下,FECO2随着VE的增加而降低,尽管在再呼吸系统中这种降低较小。因此,可以避免随着VE升高而导致的FECO2降低,并防止低碳酸血症。这些结果与临床研究中获得的结果一致。