Dean S E, Keenan R L
Anesthesiology. 1982 Jun;56(6):449-52.
Thirty adults undergoing elective superficial surgery under enflurane-nitrous oxide anesthesia which intubated and breathing spontaneously via a modified Mapleson D (Brain) T-piece circuit were studied with their consent. Total fresh gas flows which were initially high were adjusted downward until minimal rebreathing (inspired CO2 tension of 5 to 10 mmHg) was present. At this point both fresh gas flow (VF) and minute volume (VE) were recorded, and the ratio of the two (VF/VE) was calculated. The mean VF/VE ratio was found to be 1.89 +/- 0.27 (SD). Linear regression was used to plot VF against VE breathing frequency, tidal volume, age, weight, and end-tidal CO2 tension. Significant correlation was found only with VE (r2 = 0.48, P less than 0.001) and frequency (r2 = 0.44, P less than 0.001). When the ratio VF/VE was plotted against the same variables, no significant correlations was found. This study showed a wide variability in the minimum VF/VE ratio which prevents rebreathing. The respiratory waveform, which was not studied, probably played a role in determining the VF/VE. Nevertheless, 87 per cent of our patients required a VF/VE ratio of 2.0 or less to prevent rebreathing. If one is especially concerned about rebreathing, VE should be measured in the VF adjusted to about twice the measured.
30名成年患者在恩氟烷-氧化亚氮麻醉下接受择期浅表手术,经患者同意,采用改良的Mapleson D(Brain)T型管回路进行气管插管并自主呼吸。最初高流量的新鲜气体总流量逐渐下调,直至出现最小程度的重复吸入(呼出气二氧化碳分压为5至10 mmHg)。此时记录新鲜气体流量(VF)和分钟通气量(VE),并计算两者的比值(VF/VE)。发现平均VF/VE比值为1.89±0.27(标准差)。采用线性回归分析,将VF与VE、呼吸频率、潮气量、年龄、体重和呼气末二氧化碳分压进行绘图。仅发现与VE(r2 = 0.48,P<0.001)和频率(r2 = 0.44,P<0.001)存在显著相关性。当将VF/VE比值与相同变量进行绘图时,未发现显著相关性。本研究表明,防止重复吸入所需的最小VF/VE比值存在很大差异。未对呼吸波形进行研究,其可能在决定VF/VE方面发挥了作用。尽管如此,87%的患者需要VF/VE比值为2.0或更低以防止重复吸入。如果特别关注重复吸入,应在将VF调整至测量值的约两倍时测量VE。