Ekedahl C, Holm S E, Bergholm A M, Jeppsson P H, Lindström J, Ludwig C
Acta Otolaryngol. 1981 Jul-Aug;92(1-2):151-5. doi: 10.3109/00016488109133250.
The intention of prescribing antibiotic treatment must be to achieve a concentration of the agent within the infected tissue well above th MIC or the bacteria causing the infection. As a basis for further clinical studies on antibiotic concentrations in maxillary sinus mucosa in humans, determinations of biologically active penicillin V in the mucous membranes of the maxillary sinus and the buccal mucose as well as in tissue fluids and tissue from subcutaneously implanted tissue cages in rabbits were made. Several experimental conditions were studied, with the purpose of establishing optimal conditions with regard to tissue sampling, blood contamination, prediffusion time, etc. Penicillin V was shown to have a good penetration into mucosal tissue in the rabbit, even at low perfusion pressure.
开具抗生素治疗的目的必须是使感染组织内药物浓度远高于引起感染的细菌的最低抑菌浓度（MIC）。作为进一步关于人类上颌窦黏膜抗生素浓度临床研究的基础，对上颌窦黏膜和颊黏膜、组织液以及兔皮下植入组织笼中的组织内生物活性青霉素V进行了测定。研究了几种实验条件，目的是确定在组织采样、血液污染、预扩散时间等方面的最佳条件。结果表明，即使在低灌注压力下，青霉素V在兔黏膜组织中也具有良好的渗透性。
