Holm S E, Ekedahl C, Bergholm A M
Scand J Infect Dis Suppl. 1978(14):214-20.
Different experimental models were applied to study the pharmacokinetics of antibiotics in "interstitial fluid" ("i.f.") in rabbits. Two types of tissue cages were used and the results from these experiments were compared with those obtained analysing the antibiotic concentration in the mucous membrane of the oral bucca and maxillary sinus in rabbits. A similar determination was done in the mucous membrane of sinus in man. The concentration of antibiotics in the "i.f." from steel-net chambers in rabbits closely follows that of the mucous membranes of the maxillary sinus in man and the oral bucca in rabbits. Experimental bacterial infections of the tissue cages resulted in decreased amounts of biologically active antibiotics in the "i.f." for some antibiotics compared to that of the uninfected cages. An increase of the concentration of antibiotics in the infected cages was noted simultaneously with a decrease in the number of viable bacteria during the healing process. The clinical significance of the models will be discussed.
应用不同的实验模型研究抗生素在兔“组织间液”（“i.f.”）中的药代动力学。使用了两种类型的组织笼，并将这些实验结果与通过分析兔口腔颊黏膜和上颌窦黏膜中抗生素浓度所获得的结果进行比较。在人的鼻窦黏膜中也进行了类似的测定。兔的钢丝网笼组织间液中抗生素的浓度与人类上颌窦黏膜以及兔口腔颊黏膜中的浓度密切相关。与未感染的笼子相比，对组织笼进行实验性细菌感染导致某些抗生素在“i.f.”中的生物活性抗生素量减少。在愈合过程中，观察到感染笼子中抗生素浓度增加，同时活细菌数量减少。将讨论这些模型的临床意义。
