Aasjord P, Nyland H
Acta Pathol Microbiol Scand C. 1981 Oct;89(5):333-8. doi: 10.1111/j.1699-0463.1981.tb02709.x.
Antibodies to staphylococcal lipoteichoic acid (LTA) were determined in serum and in cerebrospinal fluid (CSF) from a group of patients with multiple sclerosis (MS) and a group of healthy individuals. Sera from 11 out of 74 MS patients, i.e. 15 per cent, contained precipitating antibodies demonstrated by the double diffusion in agar test, compared to 48 out of 94 control sera, i.e. 51 per cent. By using an indirect haemagglutination test, antibodies to LTA were found in all sera from both patients and controls. On the other hand, LTA antibodies were detected in a higher proportion of the CSF samples from MS patients than from controls. A reduced serum to CSF ration of LTA antibodies compared with the ratio for a reference antibody was demonstrated in 7 out of 10 MS patients, suggesting a local synthesis within the central nervous system. Absorption of seven MS CSF samples with LTA removed one to three of the cathodic oligoclonal IgG bands demonstrated by agarose electrophoresis and reduced the IgG concentration.
在一组多发性硬化症（MS）患者和一组健康个体的血清及脑脊液（CSF）中测定了抗葡萄球菌脂磷壁酸（LTA）抗体。74例MS患者中有11例血清（即15%）通过琼脂双向扩散试验显示含有沉淀抗体，而94例对照血清中有48例（即51%）含有沉淀抗体。通过间接血凝试验，在患者和对照的所有血清中均发现了抗LTA抗体。另一方面，MS患者脑脊液样本中检测到LTA抗体的比例高于对照组。10例MS患者中有7例显示，与参考抗体的比例相比，LTA抗体的血清与脑脊液比例降低，提示在中枢神经系统内有局部合成。用LTA吸收7份MS脑脊液样本后，琼脂糖电泳显示的一至三条阴极寡克隆IgG带消失，IgG浓度降低。
