Ford H C
Clin Biochem. 1985 Feb;18(1):3-13. doi: 10.1016/s0009-9120(85)80016-3.
Qualitative and quantitative abnormalities in protein and non-protein components of serum and plasma in patients with multiple sclerosis have been the subjects of numerous reports. In this review many of the more recent observations are documented and evaluated. It is concluded that at present the welter of information that has been gathered does not contribute in any major, coherent way to our understanding of the etiology or pathogenesis of the disorder. Several of the abnormalities that have been observed may be future candidates for biochemical markers for multiple sclerosis; at present none is sufficiently reliable, distinctive or easily performed to warrant the status of a useful diagnostic or prognostic test.
血清和血浆中蛋白质及非蛋白质成分的定性和定量异常在多发性硬化症患者中一直是众多报告的主题。在这篇综述中，记录并评估了许多最新的观察结果。得出的结论是，目前收集到的大量信息并没有以任何主要的、连贯的方式有助于我们理解该疾病的病因或发病机制。观察到的一些异常情况可能是未来多发性硬化症生化标志物的候选者；目前还没有一个足够可靠、独特或易于操作，足以获得有用的诊断或预后测试的地位。
