Demling R H, Manohar M, Will J
Chest. 1978 Aug;74(2):196-9. doi: 10.1378/chest.74.2.196.
Administration of glucagon has been shown to decrease pulmonary vascular resistance, but its primary site of action is undetermined. Whether this is on the arterial or venous side of the capillary would be reflected in the microvascular hydrostatic pressure. We used the pulmonary flow of lymph, a sensitive index of the transvascular fluid filtration rate, to monitor the microvascular hydrostatic pressure. Eight unanesthetized sheep with a surgically created long-term fistula for monitoring pulmonary lymph were given a 3-mg bolus of glucagon after a baseline period. We found no change in pulmonary arterial or left atrial pressures but noted a significant increase in cardiac output and a decrease in pulmonary resistance. The flow of pulmonary lymph increased by 50 percent for 30 minutes after administration of glucagon, and the protein content of the lymph decreased by 15 percent, indicating a large increase in the microvascular hydrostatic pressure. From these data, we calculated a decrease in arterial resistance from 60 percent to 30 percent of the total and, subsequently, an increase of 6 cm H2O in the microvascular hydrostatic pressure. Administration of glucagon, therefore, decreases the arterial resistance while increasing microvascular pressure in the process.
已证明给予胰高血糖素可降低肺血管阻力，但其主要作用部位尚未确定。这一作用是在毛细血管的动脉侧还是静脉侧，会反映在微血管静水压上。我们使用肺淋巴流量（一种反映跨血管液体滤过率的敏感指标）来监测微血管静水压。对8只通过手术建立长期瘘管以监测肺淋巴的未麻醉绵羊，在基线期后给予3毫克胰高血糖素推注。我们发现肺动脉压或左心房压没有变化，但心输出量显著增加，肺阻力降低。给予胰高血糖素后30分钟内，肺淋巴流量增加了50%，淋巴蛋白含量降低了15%，这表明微血管静水压大幅升高。根据这些数据，我们计算出动脉阻力从总阻力的60%降至30%，随后微血管静水压升高了6厘米水柱。因此，给予胰高血糖素在降低动脉阻力的同时，会使微血管压力升高。
