McNair P, Madsbad S, Christiansen C, Faber O K, Transbøl I, Binder C
Diabetologia. 1978 Aug;15(2):87-90. doi: 10.1007/BF00422250.
Bone mineral content was measured by photon absorptiometry in 215 insulin treated diabetic out-patients aged 7--70 years. As bone mass increases until the age of 20--25 years, patients were so selected that all remained within the same phase of bone mineral storage throughout the entire course of their diabetes. Other criteria for exclusion were diseases or drugs interfering with mineral metabolism and previous use of oral antidiabetic agents. As a group the patients demonstrated a bone mineral deficit of 9.8% compared with sex- and age-matched controls (P less than 0.001). Comparison between patients who had developed diabetes before the age of 20 years and after that of 25 years revealed deficits of 14% and 7%, respectively (P less than 0.001). Sex differences were not observed. The initiation of osteopenia seemed to coincide with the onset of clinical diabetes mellitus, and significantly reduced bone mineral content was observed after 2 years of diabetes (P less than 0.001). After 3--5 years the osteopenia appeared to attain a stable level.
采用光子吸收法对215名年龄在7至70岁之间接受胰岛素治疗的糖尿病门诊患者进行了骨矿物质含量测定。由于骨量在20至25岁之前会持续增加，因此所选患者在整个糖尿病病程中都处于相同的骨矿物质储存阶段。其他排除标准包括干扰矿物质代谢的疾病或药物以及既往使用口服降糖药的情况。与性别和年龄匹配的对照组相比，该组患者的骨矿物质缺乏率为9.8%（P<0.001）。20岁之前和25岁之后患糖尿病的患者之间的比较显示，缺乏率分别为14%和7%（P<0.001）。未观察到性别差异。骨质减少似乎与临床糖尿病的发病同时出现，糖尿病2年后观察到骨矿物质含量显著降低（P<0.001）。3至5年后，骨质减少似乎达到稳定水平。
