Larsen M J, Richards A, Fejerskov O
Calcif Tissue Int. 1981;33(5):541-4. doi: 10.1007/BF02409486.
Sodium fluoride 10, 20 or 40 mg/kg body weight was given intraperitoneally to rats (6-11 days old and 90-95 days old). Blood analyses showed an initial increase in plasma fluoride concentration. The subsequent decrease in fluoride was paralleled by a decrease in total plasma calcium. These plasma concentrations were normal at blood collection 4 days after fluoride injection. The baby rats differed from the older rats in that their initial plasma calcium was higher and that the drop in plasma calcium concentration was less pronounced than in the old rats. A diet low in calcium and phosphate enhanced the effects of fluoride on total plasma calcium. The data indicate that the effect of large doses of fluoride on lowering the plasma calcium level is modified by the calcium intake.
将10、20或40毫克/千克体重的氟化钠腹腔注射给大鼠（6 - 11日龄和90 - 95日龄）。血液分析显示血浆氟浓度最初升高。随后氟的减少与血浆总钙的减少平行。在注射氟后4天采血时，这些血浆浓度正常。幼鼠与成年大鼠的不同之处在于，幼鼠最初的血浆钙较高，且血浆钙浓度的下降比成年大鼠不明显。低钙和低磷饮食增强了氟对血浆总钙的影响。数据表明，钙摄入量会改变大剂量氟降低血浆钙水平的作用。
