Yoshida H, Huggins C
Jikken Dobutsu. 1981 Jul;30(3):303-5. doi: 10.1538/expanim1978.30.3_303.
Female Sprague-Dawley rats were given 1.25mg testosterone propionate subcutaneously within 24 hours after birth and 30mg 7, 8, 12-trimethylbenz (a) anthracene per 1 kg of body weight intravenously at 50 days of age. In these neonatally androgenized rats, the increase of the anogenital distance, aplasia or hypoplasia of the vagina, persistent estrus on the vaginal smears and eosinophilic substance in mammary glands were observed, with no corpus luteum formation in the ovaries, and the induction of mammary carcinomas by 7, 8, 12-trimethylbenz (a) anthracene was strongly suppressed.
雌性斯普拉格-道利大鼠在出生后24小时内皮下注射1.25毫克丙酸睾酮，并在50日龄时静脉注射每1千克体重30毫克的7,8,12-三甲基苯并(a)蒽。在这些新生期雄激素化的大鼠中，观察到肛门生殖器距离增加、阴道发育不全或发育不良、阴道涂片显示持续发情以及乳腺中出现嗜酸性物质，卵巢中无黄体形成，并且7,8,12-三甲基苯并(a)蒽诱导的乳腺癌受到强烈抑制。
