Tsuji T, Tokuyama K, Naito K, Okazaki S, Shinohara T
Gastroenterol Jpn. 1977;12(1):69-75. doi: 10.1007/BF02774005.
A case of alpha-feto protein (AFP) positive hepatic cell carcinoma has been presented in which the appearance of a mono-clonal gammopathy can be explained by persistent infection with HB virus (HBV). The patient, a fifty year old male, developed acute jaundice with hepatitis in July, 1952, and died of an hepatic cell carcinoma in December, 1973. The interest of this case lies in the fact that during the seven months prior to be patient's demise, a mono-clonal gammopathy of IgG (L type), together with positive titeres for HBs Ag (adr) and AFP, was demonstrated.
本文报告了一例甲胎蛋白（AFP）阳性的肝细胞癌病例，其中单克隆丙种球蛋白病的出现可由乙型肝炎病毒（HBV）持续感染来解释。患者为一名50岁男性，1952年7月患急性黄疸型肝炎，1973年12月死于肝细胞癌。该病例的有趣之处在于，在患者死亡前的七个月里，发现了IgG（L型）单克隆丙种球蛋白病，同时乙肝表面抗原（adr）和AFP滴度呈阳性。
