Tsuji T, Nagashima H
Gastroenterol Jpn. 1981 Dec;16(6):568-75. doi: 10.1007/BF02813791.
Follow-up studies were conducted in the patients with chronic active hepatitis treated 10 years ago with tiopronin (TP) or corticosteroids (CS). HB surface antigen (HBsAg) was measured in previously collected paraffin embedded liver sections by enzyme-labelled antibody technique. Of 72 cases examined, 15 cases were treated with TP only (8 cases) and combination with CS (7 cases), 38 cases with CS and 19 cases not treated with TP or CS (control group). Two deaths occurred in TP group (each 1 case in the single and combination treatments) in the 9th year due to bleeding of oesophageal varices in a chronic aggressive hepatitis (2B type) with HBsAg diffusely distributed in liver tissue. Two deaths were found in CS group and 4 in the control group. No significant difference as noted in the rehabilitation rate in HBsAg negative cases of TP group and CS group versus the control group. In the positive cases, the rehabilitation rate was found to be 66.7% in the CS group compared with 0% in the non-CS group, and each 3 cases out of 5 rehabilitated by the single and combination treatments with TP respectively.
对10年前用硫普罗宁（TP）或皮质类固醇（CS）治疗的慢性活动性肝炎患者进行了随访研究。采用酶标抗体技术检测先前收集的石蜡包埋肝组织切片中的乙肝表面抗原（HBsAg）。在检查的72例患者中，15例仅接受TP治疗（单药治疗8例，联合治疗7例），38例接受CS治疗，19例未接受TP或CS治疗（对照组）。TP组有2例死亡（单药治疗和联合治疗各1例），发生在第9年，死于慢性侵袭性肝炎（2B型）伴肝组织中HBsAg弥漫性分布导致的食管静脉曲张出血。CS组有2例死亡，对照组有4例死亡。TP组和CS组HBsAg阴性病例的康复率与对照组相比无显著差异。在阳性病例中，CS组的康复率为66.7%，非CS组为0%，TP单药治疗和联合治疗分别有5例中的3例康复。
