Kark J D, Smith A H, Hames C G
Br Med J (Clin Res Ed). 1982 Jan 16;284(6310):152-4. doi: 10.1136/bmj.284.6310.152.
Several human studies have shown an inverse relation between vitamin A intake (and serum concentrations of retinol and carotene) and cancer. Serum cholesterol concentrations have also been reported in inverse relation to cancer. In a study of 3102 people in Evans County, Georgia, who were followed for over 12-14 years to assess the incidence of cancer there was an inverse association between the risk of cancer and both serum retinol and serum cholesterol concentrations. The data also showed an unexpectedly strong correlation between serum retinol and total cholesterol concentrations. The inverse relationship with cancer was stronger with serum retinol than with cholesterol, which suggested that the association with cholesterol might be secondary. This suggestion may also explain the cholesterol-cancer association reported in several other cohort studies. Further studies of the relation between serum concentrations of cholesterol, retinol, and carotene and the incidence of cancer are needed.
多项人体研究表明，维生素A摄入量（以及血清视黄醇和胡萝卜素浓度）与癌症之间存在负相关关系。血清胆固醇浓度也被报道与癌症呈负相关。在佐治亚州埃文斯县对3102人进行的一项研究中，对他们进行了超过12至14年的随访以评估癌症发病率，结果发现癌症风险与血清视黄醇和血清胆固醇浓度之间均存在负相关。数据还显示血清视黄醇与总胆固醇浓度之间存在出乎意料的强相关性。视黄醇与癌症的负相关关系比胆固醇更强，这表明与胆固醇的关联可能是次要的。这一观点也可能解释了其他几项队列研究中报道的胆固醇与癌症的关联。需要进一步研究血清胆固醇、视黄醇和胡萝卜素浓度与癌症发病率之间的关系。
