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丝状真菌总状毛霉在恒化器培养细胞中核糖体功能的生长速率依赖性调节

Growth-rate-dependent adjustment of ribosome function in chemostat-grown cells of the fungus Mucor racemosus.

作者信息

Ross J F, Orlowski M

出版信息

J Bacteriol. 1982 Feb;149(2):650-3. doi: 10.1128/jb.149.2.650-653.1982.

DOI:10.1128/jb.149.2.650-653.1982
PMID:6799491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC216554/
Abstract

The dimorphic fungus Mucor racemosus was grown as a yeast in a chemostat. Cellular growth rates were varied over a fourfold range under an atmosphere of N2 and over an eightfold range under CO2. Under either atmosphere, an increase in the cellular growth rate resulted in increases in (i) the cellular ribosome concentration, (ii) the percentage of ribosomes active in protein synthesis, and (iii) the rate of polypeptide chain elongation. The rate of protein synthesis in this organism can therefore be regulated by adjustment of all of these mechanisms.

摘要

双态真菌总状毛霉在恒化器中作为酵母生长。在氮气气氛下,细胞生长速率在四倍范围内变化,在二氧化碳气氛下则在八倍范围内变化。在任何一种气氛下,细胞生长速率的增加都会导致以下方面的增加:(i)细胞核糖体浓度,(ii)活跃于蛋白质合成的核糖体百分比,以及(iii)多肽链延伸速率。因此,该生物体中的蛋白质合成速率可以通过调节所有这些机制来调控。

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Growth-rate-dependent adjustment of ribosome function in chemostat-grown cells of the fungus Mucor racemosus.丝状真菌总状毛霉在恒化器培养细胞中核糖体功能的生长速率依赖性调节
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Growth rate of polypeptide chains as a function of the cell growth rate in a mutant of Escherichia coli 15.大肠杆菌15突变体中多肽链生长速率与细胞生长速率的关系
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