丝状真菌总状毛霉在恒化器培养细胞中核糖体功能的生长速率依赖性调节
Growth-rate-dependent adjustment of ribosome function in chemostat-grown cells of the fungus Mucor racemosus.
作者信息
Ross J F, Orlowski M
出版信息
J Bacteriol. 1982 Feb;149(2):650-3. doi: 10.1128/jb.149.2.650-653.1982.
Abstract
The dimorphic fungus Mucor racemosus was grown as a yeast in a chemostat. Cellular growth rates were varied over a fourfold range under an atmosphere of N2 and over an eightfold range under CO2. Under either atmosphere, an increase in the cellular growth rate resulted in increases in (i) the cellular ribosome concentration, (ii) the percentage of ribosomes active in protein synthesis, and (iii) the rate of polypeptide chain elongation. The rate of protein synthesis in this organism can therefore be regulated by adjustment of all of these mechanisms.
摘要
双态真菌总状毛霉在恒化器中作为酵母生长。在氮气气氛下，细胞生长速率在四倍范围内变化，在二氧化碳气氛下则在八倍范围内变化。在任何一种气氛下，细胞生长速率的增加都会导致以下方面的增加：（i）细胞核糖体浓度，（ii）活跃于蛋白质合成的核糖体百分比，以及（iii）多肽链延伸速率。因此，该生物体中的蛋白质合成速率可以通过调节所有这些机制来调控。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Variable rate of polypeptide chain elongation in vitro. Effect of spermidine.体外多肽链延伸的可变速率。亚精胺的作用。
Eur J Biochem. 1980 May;106(1):257-62. doi: 10.1111/j.1432-1033.1980.tb06017.x.
3
Growth-rate-dependent adjustment of ribosome function in the fungus Mucor racemosus.总状毛霉中核糖体功能的生长速率依赖性调节
Biochem J. 1981 May 15;196(2):403-10. doi: 10.1042/bj1960403.
4
The inefficiency of ribosomes functioning in Escherichia coli growing at moderate rates.在中等生长速率下生长的大肠杆菌中核糖体功能的低效性。
J Gen Microbiol. 1980 Jan;116(1):165-71. doi: 10.1099/00221287-116-1-165.
5
Molecular weights of the ribosomal ribonucleic acid of fungi.真菌核糖体核糖核酸的分子量
Arch Mikrobiol. 1971;80(3):191-204. doi: 10.1007/BF00410121.
6
The adaptive responses of Escherichia coli to a feast and famine existence.大肠杆菌对丰饶与匮乏生存环境的适应性反应。
Adv Microb Physiol. 1971;6:147-217. doi: 10.1016/s0065-2911(08)60069-7.
7
Growth rate of polypeptide chains as a function of the cell growth rate in a mutant of Escherichia coli 15.大肠杆菌15突变体中多肽链生长速率与细胞生长速率的关系
J Mol Biol. 1971 Feb 14;55(3):563-8. doi: 10.1016/0022-2836(71)90337-8.
8
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9
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J Mol Biol. 1974 Jun 15;86(1):1-9. doi: 10.1016/s0022-2836(74)80002-1.
10
Chain growth rate of -galactosidase during exponential growth and amino acid starvation.
J Mol Biol. 1973 Mar 25;75(1):109-18. doi: 10.1016/0022-2836(73)90532-9.
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