Miles K, Quintáns J, Chelmicka-Schorr E, Arnason B G
J Neuroimmunol. 1981 Mar;1(1):101-5. doi: 10.1016/0165-5728(81)90012-6.
Sympathetic nerve endings were destroyed with 6-hydroxydopamine (6-OHDA) and the response to thymus-dependent and -independent antigens compared in 6-OHDA-treated and control mice. A significantly enhanced plaque-forming cell response to 2 thymus-independent antigens was observed in the 6-OHDA-treated mice; in contrast the response to a thymus-dependent antigen was normal. The findings point to selective modulation of antibody response by the sympathetic nervous system.
用6-羟基多巴胺（6-OHDA）破坏交感神经末梢，并比较6-OHDA处理的小鼠和对照小鼠对胸腺依赖性和非依赖性抗原的反应。在6-OHDA处理的小鼠中观察到对2种非胸腺依赖性抗原的噬斑形成细胞反应显著增强；相比之下，对胸腺依赖性抗原的反应正常。这些发现表明交感神经系统对抗体反应有选择性调节作用。
