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小鼠疟疾中的免疫抑制。I. 对III型肺炎球菌多糖的反应。

Immunosuppression in murine malaria. I. Response to type III pneumococcal polysaccharide.

作者信息

McBride J S, Micklem H S, Ure J M

出版信息

Immunology. 1977 May;32(5):635-44.

Abstract

Acute Plasmodium yoelii yoelii and chronic Plasmodium berghei malaria infections of CBA mice were accompanied by a reduced capacity to give an antibody response to type III pneumococcal polysaccharide (SIII). The depression of response initiated by acute malaria persisted for several weeks after recovery from clinical infection. During chronic infection, and at the peak of acute parasitaemia, virtually no response to SIII was detected. A substance which crossreacted serologically with SIII was found in blood cells of infected mice. The results suggest that antigen-specific, as well as non-specific, factors may contribute to the depression of the response to this antigen.

摘要

约氏疟原虫急性感染和伯氏疟原虫慢性感染的CBA小鼠,对III型肺炎球菌多糖(SIII)产生抗体反应的能力降低。急性疟疾引发的反应抑制在临床感染恢复后持续数周。在慢性感染期间以及急性寄生虫血症高峰期,几乎检测不到对SIII的反应。在感染小鼠的血细胞中发现了一种与SIII发生血清学交叉反应的物质。结果表明,抗原特异性以及非特异性因素可能导致对该抗原反应的抑制。

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