鼠疟中的免疫抑制。II. 对牛血清白蛋白的初次反应。
Immunosuppression in murine malaria. II. The primary response to bovine serum albumin.
作者信息
McBride J S, Micklem H S
出版信息
Immunology. 1977 Aug;33(2):253-9.
Abstract
The primary antibody response to alumadsorbed bovine serum albumin was depressed in CBA mice infected with Plasmodium yoelii yoelii. Responses initiated within approximately 3 weeks of this malaria infection were reduced in quantity, but not in avidity. Responses initated later were normal. A depressed primary response was also seen in infected compared to control splenectomized mice; this was accompanied by impaired priming for a secondary response.
摘要
感染约氏疟原虫的CBA小鼠对明矾吸附牛血清白蛋白的初次抗体反应受到抑制。在这种疟疾感染约3周内启动的反应数量减少，但亲和力未降低。稍后启动的反应正常。与对照脾切除小鼠相比，感染小鼠也出现了初次反应受抑制的情况；这伴随着二次反应的启动受损。
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