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鼠疟中的免疫抑制。II. 对牛血清白蛋白的初次反应。

Immunosuppression in murine malaria. II. The primary response to bovine serum albumin.

作者信息

McBride J S, Micklem H S

出版信息

Immunology. 1977 Aug;33(2):253-9.

PMID:608688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445344/
Abstract

The primary antibody response to alumadsorbed bovine serum albumin was depressed in CBA mice infected with Plasmodium yoelii yoelii. Responses initiated within approximately 3 weeks of this malaria infection were reduced in quantity, but not in avidity. Responses initated later were normal. A depressed primary response was also seen in infected compared to control splenectomized mice; this was accompanied by impaired priming for a secondary response.

摘要

感染约氏疟原虫的CBA小鼠对明矾吸附牛血清白蛋白的初次抗体反应受到抑制。在这种疟疾感染约3周内启动的反应数量减少,但亲和力未降低。稍后启动的反应正常。与对照脾切除小鼠相比,感染小鼠也出现了初次反应受抑制的情况;这伴随着二次反应的启动受损。

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本文引用的文献

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Exclusion chromatography.排阻色谱法。
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Factors influencing the immune response. I. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intravenous injection of bovine serum albumin in rabbits.影响免疫反应的因素。I. 抗原物理状态及淋巴细胞增殖对家兔静脉注射牛血清白蛋白反应的影响
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Chemical and serological studies with an iodine-containing synthetic immunological determinant 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) and related compounds.对含碘合成免疫决定簇4-羟基-3-碘-5-硝基苯乙酸(NIP)及相关化合物的化学和血清学研究。
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The validity of the ammonium sulphate precipitation technique of estimation of antibody amount and avidity.用于估计抗体量和亲和力的硫酸铵沉淀技术的有效性。
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