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在大鼠肝提取物中,糖原合酶D转化为合酶I的过程中存在一种中间合酶形式。

Presence of an intermediate synthase form during the conversion of glycogen synthase D into synthase I in rat liver extract.

作者信息

Tan A W

出版信息

Biochem J. 1981 Oct 15;200(1):169-72. doi: 10.1042/bj2000169.

DOI:10.1042/bj2000169
PMID:6800357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163515/
Abstract

When synthase D was converted into synthase I in a liver extract, it progressed through a synthase form with activity characteristics that could not be explained by a mixture of the original synthase D and the final product, synthase I. This form was distinguished by an affinity for UDP-glucose, in the absence of glucose 6-phosphate, which was intermediate between those of the two known forms.

摘要

当合酶D在肝脏提取物中转化为合酶I时,它会经过一种具有活性特征的合酶形式,这种活性特征无法用原始合酶D和最终产物合酶I的混合物来解释。这种形式的特点是在没有6-磷酸葡萄糖的情况下对UDP-葡萄糖具有亲和力,其亲和力介于两种已知形式之间。

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Presence of an intermediate synthase form during the conversion of glycogen synthase D into synthase I in rat liver extract.在大鼠肝提取物中,糖原合酶D转化为合酶I的过程中存在一种中间合酶形式。
Biochem J. 1981 Oct 15;200(1):169-72. doi: 10.1042/bj2000169.
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本文引用的文献

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STUDIES ON UDPG: ALPHA-1,4-GLUCAN ALPHA-4-GLUCOSYLTRANSFERASE. VII. CONVERSION OF THE ENZYME FROM GLUCOSE-6-PHOSPHATE-DEPENDENT TO INDEPENDENT FORM IN LIVER.尿苷二磷酸葡萄糖:α-1,4-葡聚糖α-4-葡萄糖基转移酶的研究。VII. 肝脏中该酶从依赖葡萄糖-6-磷酸形式向非依赖形式的转变
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STUDIES ON UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE. IV. PURIFICATION AND CHARACTERIZATION OF TWO FORMS FROM RABBIT SKELETAL MUSCLE.尿苷二磷酸葡萄糖-α-葡聚糖转葡萄糖基酶的研究。IV. 兔骨骼肌中两种形式的纯化与特性分析
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Phosphorylation of rabbit skeletal muscle glycogen synthase by cyclic AMP-dependent protein kinase and dephosphorylation of the synthase by phosphatases.环磷酸腺苷依赖性蛋白激酶对兔骨骼肌糖原合酶的磷酸化作用以及磷酸酶对该合酶的去磷酸化作用。
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An on-off mechanism for liver glycogen synthetase activity.肝糖原合成酶活性的开关机制。
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Effect of prostaglandin E 1 administration on the liver glycogen synthetase and phosphorylase systems.
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The regulation of liver glycogen synthetase D phosphatase by ATP and glucose.
Biochem Biophys Res Commun. 1973 Jul 2;53(1):164-71. doi: 10.1016/0006-291x(73)91415-0.
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Regulation of muscle glycogen synthetase by metabolites. Differential effects on the I and D forms.代谢物对肌肉糖原合成酶的调节。对I型和D型的不同影响。
Biochemistry. 1968 Jan;7(1):56-66. doi: 10.1021/bi00841a009.
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Oral glucose effect on glycogen synthetase and phosphorylase in heart. Muscle and liver.
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10
Glycogen synthase- "R": the occurrence and significance of a previously unknown form of GS, found in metabolically active human leucocytes.糖原合酶 - “R”:在代谢活跃的人类白细胞中发现的一种此前未知形式的糖原合酶的存在及其意义。
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