Heikkinen J, Ylöstalo P, Mäentausta O, Jänne O
Contraception. 1982 Jan;25(1):89-95. doi: 10.1016/0010-7824(82)90021-x.
Twenty-nine women were treated with biphasic combined oral contraceptive pills containing ethinyl estradiol 0.05 mg and levonorgestrel 0.050-0.125 mg. Serum primary bile acids (cholic acid and chenodeoxycholic acid) and one secondary bile acid (deoxycholic acid) were measured by radioimmunoassay. The serum samples were collected before the treatment and at one, three and twelve months during the treatment. No significant changes were found in these bile acid levels during the treatment. The ratio of cholic/chenodeoxycholic acid did not change either. No pathological values were found in the conventional liver function tests although serum alanine aminotransferase activity was significantly increased after twelve months' treatment. It can therefore be concluded that the present contraceptive pill does not cause any liver dysfunction detectable by bile acid measurements of other "classical" liver function tests.
29名女性接受了含有0.05毫克炔雌醇和0.050 - 0.125毫克左炔诺孕酮的双相复方口服避孕药治疗。通过放射免疫分析法测定血清中的初级胆汁酸（胆酸和鹅去氧胆酸）以及一种次级胆汁酸（脱氧胆酸）。在治疗前以及治疗期间的第1、3和12个月采集血清样本。治疗期间这些胆汁酸水平未发现显著变化。胆酸/鹅去氧胆酸的比值也没有改变。尽管在治疗12个月后血清丙氨酸转氨酶活性显著升高，但常规肝功能检查未发现病理值。因此可以得出结论，目前的避孕药不会导致通过胆汁酸测量或其他“经典”肝功能检查可检测到的任何肝功能障碍。
