Gibo Y, Nagata A, Kiyosawa K, Furuta S
Gastroenterol Jpn. 1981 Dec;16(6):576-81. doi: 10.1007/BF02813792.
Liver specimens were obtained from 21 non-A, non-B hepatitis patients when their serum transaminase levels were still elevated. The specimens were investigated by transmission electron microscope in order to investigate the presence of the structure relating to this type of hepatitis. Intranuclear electron-dense aggregates of virus-like particles were observed in 2 out of 21 cases. One was an unresolved acute hepatitis case with short-incubation posttransfusion type, and the other was a chronic persistent hepatitis case without bloodtransfusion. The size of these particles varied from 22 to 28 nm in diameter. The incidence of hepatocytes with the particles was approximately 2 to 3% of the cells investigated. These particles may represent an intranuclear alteration in close association with one type of non-A, non-B hepatitis.
从21例非甲非乙型肝炎患者血清转氨酶水平仍升高时获取肝脏标本。为了研究与这类肝炎相关的结构的存在情况，用透射电子显微镜对标本进行了检查。在21例中的2例中观察到核内有病毒样颗粒的电子致密聚集体。1例是未愈的急性肝炎病例，为短潜伏期输血后型，另1例是无输血史的慢性持续性肝炎病例。这些颗粒的直径大小在22至28纳米之间。含有这些颗粒的肝细胞发生率约为所检查细胞的2%至3%。这些颗粒可能代表与一种非甲非乙型肝炎密切相关的核内改变。
