Dhingra S, Katoch S S, Malhotra R K
Exp Pathol (Jena). 1978;15(2):97-104. doi: 10.1016/s0014-4908(78)80073-8.
The effects of denervation on the three gastrocnemii muscle of chick have been studied with regard to the lipid and lipase distribution on the different fibre types, for a maximum period of 8 weeks after unilateral sciatectomy. The observations exhibit a loss of intrafibrillar lipids which is not on account of enhanced lipolytic activity within the muscle fibres. The lipases also exhibit lowered intrafibrillar activity during the corresponding period and may be one of the several lytic enzymes responsible for the degenerative changes in the muscle cells. The differential response of the three muscles, the muscle bundles in each of them and the different fibre types, to denervation, has been explained on the basis of the balance maintained between the trophic and the intrinsic regulatory mechanisms.
在单侧坐骨神经切除术后长达8周的时间里，研究了去神经支配对雏鸡三块腓肠肌的影响，涉及不同纤维类型上脂质和脂肪酶的分布。观察结果显示肌原纤维内脂质减少，这并非由于肌纤维内脂解活性增强所致。在相应时期，脂肪酶的肌原纤维内活性也降低，并且可能是导致肌肉细胞发生退行性变化的几种裂解酶之一。基于营养调节机制和内在调节机制之间维持的平衡，解释了这三块肌肉、每块肌肉中的肌束以及不同纤维类型对去神经支配的不同反应。
