[选择对实验小鼠对硫替派细胞遗传学效应敏感性的影响]
[Influence of selection on the sensitivity of laboratory mice to the cytogenetic effect oof thioTEPA].
作者信息
Malashenko A M, Kryshkina V P, Surkova N I
出版信息
Genetika. 1982 Feb;18(2):241-7.
The influence of selection and inbreeding on the sensitivity of laboratory mice to cytogenetic effect of thioTEPA was studied. Selection was started among genetically heterogenous "synthetic" population. The sensitivity of mice was estimated by the frequency of bone marrow cells with chromosome damages in males 24 hours after the treatment with 5 mg/kg of thioTEPA dose intraperitoneally. As a result, genetic determination of sensitivity to the mutagen was demonstrated and the TPS strain was developed which was 3 to 4 times more sensitive than "normal" standard strains.
研究了选择和近亲繁殖对实验室小鼠对硫代磷酸三乙酯细胞遗传学效应敏感性的影响。选择始于基因异质的“合成”群体。通过腹腔注射5mg/kg硫代磷酸三乙酯剂量24小时后雄性小鼠骨髓细胞染色体损伤的频率来估计小鼠的敏感性。结果表明，对诱变剂的敏感性存在遗传决定因素，并培育出了TPS品系，其敏感性比“正常”标准品系高3至4倍。
Zotero 插件