Sherman K E, Dodd R Y
J Infect Dis. 1982 Mar;145(3):383-6. doi: 10.1093/infdis/145.3.383.
The incidence of elevated levels of alanine aminotransferase (ALT) in the serum of volunteer blood donors from different geographic areas of the United States was evaluated. Five regional blood collection centers participated by collecting samples randomly from volunteer blood donors. Serum samples were centrally tested for elevated ALT levels, and a sociodemographic questionnaire was sent to donors with elevated ALT levels and to a randomly selected group with normal levels. Significant regional variation was found in the incidence of elevated ALT levels. Age, sex, and the use of alcohol were all significantly associated with elevated ALT levels. These preliminary data are important in the consideration of a program to screen blood donors for elevated ALT levels in serum.
对来自美国不同地理区域的无偿献血者血清中丙氨酸转氨酶（ALT）水平升高的发生率进行了评估。五个地区血液采集中心参与其中，从无偿献血者中随机采集样本。对血清样本集中检测ALT水平升高情况，并向ALT水平升高的献血者以及随机选择的ALT水平正常的组发放社会人口统计学调查问卷。发现ALT水平升高的发生率存在显著的地区差异。年龄、性别和饮酒情况均与ALT水平升高显著相关。这些初步数据对于考虑开展一项筛查无偿献血者血清ALT水平升高的项目具有重要意义。
