de Oliveira S L, da Silva M F, Soares A M, Silva C L
Department of Microbiology and Immunology, UNESP, Botucatu, SP, Brazil.
Mycopathologia. 1993 Jan;121(1):1-5. doi: 10.1007/BF01103346.
The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the Fl fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.
