恰加斯病中抗层粘连蛋白抗体
Antibodies to laminin in Chagas' disease.
作者信息
Szarfman A, Terranova V P, Rennard S I, Foidart J M, de Fatima Lima M, Scheinman J I, Martin G R
出版信息
J Exp Med. 1982 Apr 1;155(4):1161-71. doi: 10.1084/jem.155.4.1161.
Abstract
We have found that sera from humans with Chagas' disease and Rhesus monkeys infected with Trypanosoma cruzi contain IgM and IgG antibodies, which react with structures in a variety of connective tissues. These antibodies react with laminin but not with various other purified connective tissue components like collagen types I, III, IV, and V, fibronectin, heparan sulfate (BM-1) proteoglycan, or chondronectin. The tissue-reacting antibodies were isolated by absorption to a laminin-Sepharose column. The bound fraction contained all the tissue-reacting antibodies. These antibodies strongly stained trypomastigotes and amastigotes, but weakly stained epimastigotes. These studies show that sera from T. cruzi-infected primates contain antilaminin antibodies, which may be produced by those host in response to a laminin-like molecule present in the parasite.
摘要
我们发现，患有恰加斯病的人类以及感染克氏锥虫的恒河猴的血清中含有IgM和IgG抗体，这些抗体可与多种结缔组织中的结构发生反应。这些抗体与层粘连蛋白发生反应，但不与其他各种纯化的结缔组织成分发生反应，如I型、III型、IV型和V型胶原蛋白、纤连蛋白、硫酸乙酰肝素（BM-1）蛋白聚糖或软骨粘连蛋白。通过吸附到层粘连蛋白-琼脂糖柱上分离出组织反应性抗体。结合部分包含所有组织反应性抗体。这些抗体对锥鞭毛体和无鞭毛体有强烈染色，但对前鞭毛体染色较弱。这些研究表明，来自感染克氏锥虫的灵长类动物的血清中含有抗层粘连蛋白抗体，这些抗体可能是宿主针对寄生虫中存在的类似层粘连蛋白的分子产生的。
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