恰加斯病和美洲皮肤利什曼病中针对基底膜蛋白巢蛋白的抗体。
Antibodies to basement membrane protein nidogen in Chagas' disease and American cutaneous leishmaniasis.
作者信息
Avila J L, Rojas M, Velazquez-Avila G, von der Mark H, Timpl R
出版信息
J Clin Microbiol. 1986 Nov;24(5):775-8. doi: 10.1128/jcm.24.5.775-778.1986.
Abstract
About 50 to 70% of sera from patients with American cutaneous leishmaniasis and chronic Chagas' disease possessed antibodies which reacted in enzyme and radioimmunoassays with nidogen obtained from a tumor basement membrane. The antibodies were of the immunoglobulin M and G classes in acute American cutaneous leishmaniasis but mainly of the immunoglobulin G class in chronic Chagas' disease. Similar antibodies could not be detected in patients suffering from a variety of other infectious or inflammatory diseases when compared with healthy control groups. Inhibition and immunoadsorption studies indicated a close relationship of epitopes recognized by patients' antibodies on nidogen and on another basement membrane protein, laminin. Since rabbit antisera to both proteins do not cross-react, a special nature of the epitopes involved in the reaction with patient sera is suggested. Similar epitopes may exist on various forms of Leishmania or Trypanosoma protozoa.
摘要
来自患美洲皮肤利什曼病和慢性恰加斯病患者的血清中，约50%至70%含有抗体，这些抗体在酶免疫测定和放射免疫测定中与从肿瘤基底膜获得的巢蛋白发生反应。在急性美洲皮肤利什曼病中，这些抗体属于免疫球蛋白M和G类，但在慢性恰加斯病中主要属于免疫球蛋白G类。与健康对照组相比，在患有各种其他感染性或炎症性疾病的患者中未检测到类似抗体。抑制和免疫吸附研究表明，患者抗体在巢蛋白和另一种基底膜蛋白层粘连蛋白上识别的表位之间存在密切关系。由于针对这两种蛋白的兔抗血清不发生交叉反应，提示与患者血清反应的表位具有特殊性质。类似的表位可能存在于各种形式的利什曼原虫或锥虫中。
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本文引用的文献
1
Chagas' disease; a clinical, epidemiologic, and pathologic study.恰加斯病；一项临床、流行病学及病理学研究。
Circulation. 1956 Dec;14(6):1035-60. doi: 10.1161/01.cir.14.6.1035.
2
Circulating immune complexes and anti-IgG antibodies in mucocutaneous leishmaniasis.黏膜皮肤利什曼病中的循环免疫复合物和抗IgG抗体。
Am J Trop Med Hyg. 1980 Mar;29(2):195-8. doi: 10.4269/ajtmh.1980.29.195.
3
A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers.一种快速、简单的大量纯化墨西哥利什曼原虫无鞭毛体的方法。
Parasitology. 1981 Jun;82(Pt 3):345-55. doi: 10.1017/s0031182000066889.
4
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5
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Eur J Biochem. 1984 Aug 1;142(3):493-502. doi: 10.1111/j.1432-1033.1984.tb08313.x.
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7
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Circulation. 1974 Jan;49(1):13-21. doi: 10.1161/01.cir.49.1.13.
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