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Ann Rheum Dis. 1995 Sep;54(9):740-3. doi: 10.1136/ard.54.9.740.
2
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[Immunological problems in acute rheumatic fever].[急性风湿热中的免疫学问题]
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Antibodies to laminin in Chagas' disease.恰加斯病中抗层粘连蛋白抗体
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Immunological studies on acute rheumatic fever and rheumatic heart disease.急性风湿热和风湿性心脏病的免疫学研究
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3
Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations.36种针对细胞骨架蛋白、甲状腺球蛋白和天然DNA具有抗体活性的人单克隆免疫球蛋白：免疫学研究及临床相关性
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Protective antigenic determinant of streptococcal M protein shared with sarcolemmal membrane protein of human heart.与人心肌细胞膜蛋白共有的链球菌M蛋白保护性抗原决定簇。
J Exp Med. 1982 Oct 1;156(4):1165-76. doi: 10.1084/jem.156.4.1165.
5
An immunological relationship between the group. A streptococcus and mammalian muscle.A组链球菌与哺乳动物肌肉之间的免疫关系。
J Exp Med. 1966 Oct 1;124(4):661-78. doi: 10.1084/jem.124.4.661.
6
Experimental autoimmune arthritis in mice. I. Homologous type II collagen is responsible for self-perpetuating chronic polyarthritis.小鼠实验性自身免疫性关节炎。I. 同源II型胶原蛋白是持续性慢性多关节炎的病因。
Ann Rheum Dis. 1987 Sep;46(9):691-700. doi: 10.1136/ard.46.9.691.
7
Systemic autoimmune disease arises from polyclonal B cell activation.系统性自身免疫性疾病源于多克隆B细胞活化。
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Anti-cardiolipin antibodies in ischaemic heart disease.缺血性心脏病中的抗心磷脂抗体。
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Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.在易患柯萨奇病毒B3诱导性心肌炎的小鼠中发现了针对心肌肌球蛋白亚型的自身抗体。
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Myosin: a link between streptococci and heart.肌球蛋白：链球菌与心脏之间的联系。
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风湿热：针对多种心脏、核及链球菌抗原的自身抗体。

Rheumatic fever: autoantibodies against a variety of cardiac, nuclear, and streptococcal antigens.

作者信息

Eichbaum Q G, Hughes E J, Epstein J E, Beatty D W

机构信息

Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Ann Rheum Dis. 1995 Sep;54(9):740-3. doi: 10.1136/ard.54.9.740.

DOI:10.1136/ard.54.9.740
PMID:7495346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1009990/
Abstract

OBJECTIVE

To measure antibody titres to cardiac, nuclear, and streptococcal antigens in different groups of rheumatic fever (n = 60) and control subjects (n = 80) with the aim of identifying cross reactive antigens of potential laboratory diagnostic value.

METHODS

Enzyme linked immunosorbent assays (ELISA), immunocytochemical, and electrophoretic techniques were used to measure titres of antibodies to a variety of cardiac, nuclear, and streptococcal antigens in seven groups comprising patients with rheumatic fever and control subjects.

RESULTS

Increased concentrations of antibodies to several streptococcal and cardiac antigens, in addition to increased IgA and IgG levels, were noted in sera from patients with acute rheumatic fever and chronic rheumatic heart disease. Autoantibodies to nuclear antigens were evident in three rheumatic fever sera.

CONCLUSION

Although we were unable to identify any unique cross reactivity between cardiac and streptococcal antigens, these results demonstrate that there is an exaggerated humoral response to several cardiac, nuclear and streptococcal antigens in patients with rheumatic fever.

摘要

目的

检测不同组别的风湿热患者（n = 60）和对照受试者（n = 80）针对心脏、核和链球菌抗原的抗体滴度，以识别具有潜在实验室诊断价值的交叉反应抗原。

方法

采用酶联免疫吸附测定（ELISA）、免疫细胞化学和电泳技术，检测包括风湿热患者和对照受试者在内的七组人群中针对多种心脏、核和链球菌抗原的抗体滴度。

结果

在急性风湿热患者和慢性风湿性心脏病患者的血清中，除了IgA和IgG水平升高外，还发现几种链球菌和心脏抗原的抗体浓度增加。在三份风湿热血清中可明显检测到针对核抗原的自身抗体。

结论

尽管我们未能识别出心脏和链球菌抗原之间存在任何独特的交叉反应，但这些结果表明，风湿热患者对几种心脏、核和链球菌抗原存在过度的体液反应。