风湿热：针对多种心脏、核及链球菌抗原的自身抗体。
Rheumatic fever: autoantibodies against a variety of cardiac, nuclear, and streptococcal antigens.
作者信息
Eichbaum Q G, Hughes E J, Epstein J E, Beatty D W
机构信息
Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Ann Rheum Dis. 1995 Sep;54(9):740-3. doi: 10.1136/ard.54.9.740.
OBJECTIVE
To measure antibody titres to cardiac, nuclear, and streptococcal antigens in different groups of rheumatic fever (n = 60) and control subjects (n = 80) with the aim of identifying cross reactive antigens of potential laboratory diagnostic value.
METHODS
Enzyme linked immunosorbent assays (ELISA), immunocytochemical, and electrophoretic techniques were used to measure titres of antibodies to a variety of cardiac, nuclear, and streptococcal antigens in seven groups comprising patients with rheumatic fever and control subjects.
RESULTS
Increased concentrations of antibodies to several streptococcal and cardiac antigens, in addition to increased IgA and IgG levels, were noted in sera from patients with acute rheumatic fever and chronic rheumatic heart disease. Autoantibodies to nuclear antigens were evident in three rheumatic fever sera.
CONCLUSION
Although we were unable to identify any unique cross reactivity between cardiac and streptococcal antigens, these results demonstrate that there is an exaggerated humoral response to several cardiac, nuclear and streptococcal antigens in patients with rheumatic fever.
目的
检测不同组别的风湿热患者（n = 60）和对照受试者（n = 80）针对心脏、核和链球菌抗原的抗体滴度，以识别具有潜在实验室诊断价值的交叉反应抗原。
方法
采用酶联免疫吸附测定（ELISA）、免疫细胞化学和电泳技术，检测包括风湿热患者和对照受试者在内的七组人群中针对多种心脏、核和链球菌抗原的抗体滴度。
结果
在急性风湿热患者和慢性风湿性心脏病患者的血清中，除了IgA和IgG水平升高外，还发现几种链球菌和心脏抗原的抗体浓度增加。在三份风湿热血清中可明显检测到针对核抗原的自身抗体。
结论
尽管我们未能识别出心脏和链球菌抗原之间存在任何独特的交叉反应，但这些结果表明，风湿热患者对几种心脏、核和链球菌抗原存在过度的体液反应。
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