McBride H M, Lambden P R, Heckels J E, Watt P J
J Gen Microbiol. 1981 Sep;126(1):63-7. doi: 10.1099/00221287-126-1-63.
Guinea-pig subcutaneous chambers were infected with a mixture of gonococcal variants of defined outer membrane protein profile. Survival within the chambers was a two-stage process. The initial advantage conferred by the lack of opacity-related outer membrane protein was transient and survivors were replaced by opaque colonial variants. Amongst these survivors were variants which produced opacity-related proteins (IId, IIe and IIf) not present in the initial inoculum. Thus, outer membrane protein composition is an important factor in survival in vivo.
将豚鼠皮下腔室接种具有特定外膜蛋白谱的淋球菌变体混合物。腔室内的存活情况是一个两阶段过程。缺乏与不透明相关的外膜蛋白所带来的初始优势是短暂的，存活者被不透明的菌落变体所取代。在这些存活者中有产生初始接种物中不存在的与不透明相关蛋白（IId、IIe和IIf）的变体。因此，外膜蛋白组成是体内存活的一个重要因素。
