Mayer L W
Infect Immun. 1982 Aug;37(2):481-5. doi: 10.1128/iai.37.2.481-485.1982.
The rate of change of colony opacity phenotype was determined for 12 strains of Neisseria gonorrhoeae. The average rate of change was about 2 X 10(-3) per colony-forming unit per generation with a range of 0.2 X 10(-3) to 4 X 10(-3) per colony-forming unit per generation. Transition from opaque to transparent occurred at the same rate as transition from transparent to opaque. The following factors were shown to have no effect on the transition rate: (i) the state of piliation; (ii) the number of passages as a particular phenotype; (iii) alteration in the temperature, pH, or amount of oxygen in the atmosphere during growth; (iv) the addition of any of 194 compounds or mixtures to the growth media; (v) the addition of DNase or of DNA from opaque or transparent gonococci; and (vi) incubation between the opacity-transparency transition and the change resulting in the loss of piliation was seen. Some implications of the high transition rate are discussed.
测定了12株淋病奈瑟菌菌落透明度表型的变化速率。平均变化速率约为每代每菌落形成单位2×10⁻³，范围为每代每菌落形成单位0.2×10⁻³至4×10⁻³。从不透明到透明的转变速率与从透明到不透明的转变速率相同。结果表明，以下因素对转变速率没有影响：（i）菌毛状态；（ii）作为特定表型的传代次数；（iii）生长期间温度、pH值或大气中氧气量的改变；（iv）向生长培养基中添加194种化合物或混合物中的任何一种；（v）添加DNA酶或不透明或透明淋球菌的DNA；以及（vi）在透明度 - 不透明度转变和导致菌毛丧失的变化之间进行孵育。讨论了高转变速率的一些影响。
