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(+)-儿茶素-3对肝实质毒性脂肪浸润的影响(作者译)

[The effect of (+)-cyanidanol-3 on toxic fatty infiltration of liver parenchyma (author's transl)].

作者信息

Meiss R, Rassat J, Themann H

出版信息

Arzneimittelforschung. 1982;32(2):139-40.

PMID:6802144
Abstract

Polychlorinated biphenyls, pentachlorophenol, d-galactosamine or alcohol are well known substances which produce toxic liver damage in animal experiments. Of special significance is the toxic fatty infiltration in the live parenchyma of these models. The effects following (+)-Cyanidanol-3 (Catergen)--application after liver damage was studied by qualitative and quantitative electron microscopy. (+)-Cyanidanol-3 reduces the volume density of intracytoplasmatic fat following intoxication significantly to normal values.

摘要

多氯联苯、五氯苯酚、D-半乳糖胺或酒精是在动物实验中会导致肝脏毒性损伤的知名物质。这些模型的肝实质中出现的毒性脂肪浸润具有特殊意义。通过定性和定量电子显微镜研究了肝损伤后应用(+)-儿茶素-3(Catergen)的效果。(+)-儿茶素-3能使中毒后细胞质内脂肪的体积密度显著降低至正常水平。

相似文献

1
[The effect of (+)-cyanidanol-3 on toxic fatty infiltration of liver parenchyma (author's transl)].(+)-儿茶素-3对肝实质毒性脂肪浸润的影响(作者译)
Arzneimittelforschung. 1982;32(2):139-40.
2
[On the molecular mechanism of action of (+)-cyanidanol-3 (author's transl)].关于(+)-矢车菊素-3的分子作用机制(作者译)
Arzneimittelforschung. 1979;29(5):720-4.
3
Antinecrotic effect of 3-palmitoyl-(+)-catechin against liver damage induced by galactosamine or ethanol in the rat.3-棕榈酰-(+)-儿茶素对大鼠半乳糖胺或乙醇诱导的肝损伤的抗坏死作用。
Liver. 1985 Apr;5(2):55-63. doi: 10.1111/j.1600-0676.1985.tb00215.x.
4
[Influence of silymarin and (+)-cyanidanol-3 on the HCB-induced porphyria in rats (author's transl)].
Z Gastroenterol. 1982 Jan;20(1):40-6.
5
Changes in bilirubin transport across the liver by the flavonoids (+)-cyanidanol-3 and palmitoyl-catechin.类黄酮(+)-氰定醇-3和棕榈酰儿茶素对胆红素经肝脏转运的影响。
Arzneimittelforschung. 1986 Apr;36(4):691-4.
6
[Hepatic activity of (+)-cyanidanol-3 in animal experiments].(+)-儿茶素-3在动物实验中的肝脏活性
Clin Ter. 1980 Oct 15;95(1):43-58.
7
Protective effect of (+)cyanidanol-3 in acute liver injury induced by galactosamine or carbon tetrachloride in the rat.(+)-矢车菊素-3对大鼠半乳糖胺或四氯化碳诱导的急性肝损伤的保护作用。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):285-91. doi: 10.1007/BF00499159.
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Effect of cyanidanol-3 on lysosomal enzyme activity of serum and granulocytes in chronic liver disease and active hepatitis.花青定-3对慢性肝病和活动性肝炎患者血清及粒细胞溶酶体酶活性的影响。
Int J Tissue React. 1984;6(1):75-80.
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[Effect of catergen treatment on the histochemical studies of post-alcohol lesions of the liver in rat].[促细胞分裂剂治疗对大鼠酒精性肝损伤组织化学研究的影响]
Patol Pol. 1982 Jan-Jun;33(1-2):71-84.
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The prevention by (+)-Cyanidanol-3 of hepatitis-induced changes in the disposition of imipramine in the rat.(+)-儿茶素-3对大鼠肝炎引起的丙咪嗪处置变化的预防作用。
Biochem Pharmacol. 1984 Jul 15;33(14):2179-84. doi: 10.1016/0006-2952(84)90651-8.