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(+)-儿茶素-3对肝实质毒性脂肪浸润的影响(作者译)

[The effect of (+)-cyanidanol-3 on toxic fatty infiltration of liver parenchyma (author's transl)].

作者信息

Meiss R, Rassat J, Themann H

出版信息

Arzneimittelforschung. 1982;32(2):139-40.

PMID:6802144
Abstract

Polychlorinated biphenyls, pentachlorophenol, d-galactosamine or alcohol are well known substances which produce toxic liver damage in animal experiments. Of special significance is the toxic fatty infiltration in the live parenchyma of these models. The effects following (+)-Cyanidanol-3 (Catergen)--application after liver damage was studied by qualitative and quantitative electron microscopy. (+)-Cyanidanol-3 reduces the volume density of intracytoplasmatic fat following intoxication significantly to normal values.

摘要

多氯联苯、五氯苯酚、D-半乳糖胺或酒精是在动物实验中会导致肝脏毒性损伤的知名物质。这些模型的肝实质中出现的毒性脂肪浸润具有特殊意义。通过定性和定量电子显微镜研究了肝损伤后应用(+)-儿茶素-3(Catergen)的效果。(+)-儿茶素-3能使中毒后细胞质内脂肪的体积密度显著降低至正常水平。

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