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环氧化酶抑制剂对血小板活化因子炎症效应的阻断作用。

Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.

作者信息

Vargaftig B B, Ferreira S H

出版信息

Braz J Med Biol Res. 1981 Jul;14(2-3):187-9.

PMID:6802210
Abstract
  1. The edematogenic and hyperalgesic effects of synthetic Platelet-Activating Factor (PAF-acether) on the rat paw were investigated. 2. PAF-acether induced a dose-dependent oedema and hyperalgesia. 3. These effects were partially reduced by non-steroidal anti-inflammatory agents. 4. It is suggested that the oedema and hyperalgesia in response to PAF-acether are due at least in part to the release of a cyclo-oxygenase metabolite, probably prostacyclin.
摘要
  1. 研究了合成血小板活化因子（PAF-乙醚）对大鼠爪的致水肿和痛觉过敏作用。2. PAF-乙醚诱导剂量依赖性水肿和痛觉过敏。3. 这些作用被非甾体抗炎药部分减轻。4. 提示对PAF-乙醚产生的水肿和痛觉过敏至少部分归因于环氧化酶代谢产物的释放，可能是前列环素。

相似文献

1
Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.环氧化酶抑制剂对血小板活化因子炎症效应的阻断作用。
Braz J Med Biol Res. 1981 Jul;14(2-3):187-9.
2
Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective.当环氧化酶抑制剂无效时，水杨酸盐可抑制血小板活化因子（PAF）-乙醚诱导的大鼠爪部水肿。
Prostaglandins. 1986 Nov;32(5):719-27. doi: 10.1016/0090-6980(86)90194-2.
3
Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes.血小板活化因子乙醚（PAF-乙醚）参与急性炎症和疼痛过程。
Agents Actions. 1981 Dec;11(6-7):559-62. doi: 10.1007/BF01978740.
4
Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat.血小板活化因子（PAF-乙醚）在大鼠体内局部炎症与全身血液学效应之间的相互作用。
Eur J Pharmacol. 1987 Apr 29;136(3):353-60. doi: 10.1016/0014-2999(87)90308-6.
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Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin.脂氧素A4抑制小鼠急性水肿：对阿司匹林诱导的抗水肿机制的启示。
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Pharmacological modulation of 2-methyl-carbamate-PAF induced rat paw oedema.2-甲基氨基甲酸酯-PAF诱导的大鼠爪肿胀的药理学调节
J Pharm Pharmacol. 1990 Mar;42(3):203-4. doi: 10.1111/j.2042-7158.1990.tb05388.x.
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Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium.血小板活化因子（PAF-乙醚）诱导的人血小板聚集和释放反应——乙酰水杨酸和细胞外游离钙的作用
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Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.内源性阿片类物质介导了在角叉菜胶处理的大鼠爪中由环氧化酶2选择性抑制剂诱导的痛觉减退。
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Dual inhibition of platelet-activating factor and arachidonic acid metabolism by ajmaline and effect on carrageenan-induced rat paw oedema.阿义马林对血小板活化因子和花生四烯酸代谢的双重抑制作用及其对角叉菜胶诱导的大鼠足肿胀的影响。
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Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man.血清白蛋白、吲哚美辛和组胺H1拮抗剂对实验动物和人类皮肤中血小板活化因子诱导的炎症反应的影响。
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引用本文的文献

1
The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia.PAF/PAFR 信号在酵母聚糖诱导的关节炎症性痛觉过敏中的作用。
Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):51-9. doi: 10.1007/s00210-012-0813-4. Epub 2012 Nov 28.
2
Effect of PAF on rat lung vascular permeability: role of platelets and polymorphonuclear leucocytes.血小板激活因子对大鼠肺血管通透性的影响：血小板和多形核白细胞的作用。
Br J Pharmacol. 1994 Apr;111(4):1111-6. doi: 10.1111/j.1476-5381.1994.tb14859.x.
3
Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators.
豚鼠皮肤反向被动Arthus反应中炎症反应相关机制的研究：中性粒细胞和内源性介质的作用
Br J Pharmacol. 1994 Dec;113(4):1363-71. doi: 10.1111/j.1476-5381.1994.tb17148.x.
4
Platelet activating factor potentiates rat paw oedema induced by different phlogogen agents.血小板活化因子可增强不同致炎剂诱导的大鼠爪部水肿。
Agents Actions. 1994 May;41(3-4):140-3. doi: 10.1007/BF02001907.
5
Inflammatory actions of platelet activating factor (Pafacether) in guinea-pig skin.血小板活化因子（Pafacether）在豚鼠皮肤中的炎症作用。
Br J Pharmacol. 1983 Nov;80(3):503-9. doi: 10.1111/j.1476-5381.1983.tb10722.x.
6
The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene.血小板激活因子从豚鼠肺中释放血栓素A2不依赖血小板，其机制与白三烯不同。
Br J Pharmacol. 1984 Jul;82(3):565-75. doi: 10.1111/j.1476-5381.1984.tb10795.x.
7
Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether.组胺和白三烯非依赖性豚鼠过敏性休克不能用血小板活化因子来解释。
Br J Pharmacol. 1985 Apr;84(4):801-10. doi: 10.1111/j.1476-5381.1985.tb17374.x.
8
Platelet involvement in rat paw edema induced by 2-methoxy-PAF.血小板在2-甲氧基血小板活化因子诱导的大鼠爪水肿中的作用
Inflammation. 1986 Dec;10(4):393-401. doi: 10.1007/BF00915823.
9
Failure of PAF-acether to induce in vivo neutrophil migration.血小板活化因子未能诱导体内中性粒细胞迁移。
Agents Actions. 1988 Aug;25(1-2):191-4. doi: 10.1007/BF01969111.
10
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.血小板活化因子诱导的大鼠胸膜炎的药理学调节及其在酵母聚糖所致炎症中的作用
Br J Pharmacol. 1989 Feb;96(2):363-71. doi: 10.1111/j.1476-5381.1989.tb11826.x.