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某些动物病毒的伽马射线灭活作用

Gamma ray inactivation of some animal viruses.

作者信息

Thomas F C, Davies A G, Dulac G C, Willis N G, Papp-Vid G, Girard A

出版信息

Can J Comp Med. 1981 Oct;45(4):397-9.

PMID:6802472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1320171/
Abstract

Twenty samples of animal viruses comprising 14 different viruses in 12 families were subjected to varying doses of gamma irradiation from a 60Co source in a Gamma Cell 220 (Atomic Energy of Canada Limited) to determine lethal dose levels. The dose responses appeared linear throughout inactivation. The D10 values, that is the dose necessary to reduce infectivity by one log10, ranged from less than 0.20 Megarads to approximately 0.55 Megarads. There was not a complete inverse correlation between the target size (virion core) and the D10 value.

摘要

对来自12个科的14种不同病毒的20份动物病毒样本,在伽马细胞220(加拿大原子能有限公司)中用60Co源进行不同剂量的伽马辐射,以确定致死剂量水平。在整个灭活过程中,剂量反应呈线性。D10值,即使感染力降低一个对数级所需的剂量,范围从小于0.20兆拉德到约0.55兆拉德。目标大小(病毒粒子核心)与D10值之间不存在完全的负相关。

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本文引用的文献

1
Preparation of non-infective soluble antigens with gamma radiation.用伽马辐射制备非感染性可溶性抗原。
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2
Inactivation of thirty viruses by gamma radiation.通过伽马辐射使三十种病毒失活。
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3
Recovery of viruses from field samples of raw, digested, and lagoon-dried sludges.从生污泥、消化污泥和泻湖干燥污泥的现场样本中回收病毒。
Bull World Health Organ. 1979;57(1):105-8.
4
Polioviruses and other enteroviruses in urban sewage from Laval (Canada): presence of non-vaccinal strains of poliovirus.加拿大拉瓦尔城市污水中的脊髓灰质炎病毒及其他肠道病毒:脊髓灰质炎病毒非疫苗株的存在情况
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