Förster H, Quadbeck R, Gottstein U
Int J Vitam Nutr Res Suppl. 1982;22:67-88.
In a clinical study 12 healthy volunteers consumed a standardized basal diet consecutively supplemented with either sucrose (6 days, 80-100 g/day) or xylitol (18 days, 40-100 g/day). Pre- and post-periods with normal diet were also included in the study. With the exception of a few cases of diarrhoea at the start of the xylitol administration no other clinical signs indicated treatment-related side-effects. Whereas during the xylitol period plasma cholesterol values tended to be decreased, triglyceride levels remained unaffected. Other parameters (such as urinary calcium and oxalate as well as plasma uric acid) which have been suggested to be influenced by carbohydrate consumption were in fact not altered by the dietary regimen of the present study. A variety of other serum and urinary parameters revealed also no between-treatment differences. It may be concluded from these data under the present experimental conditions that subchronic consumption of considerable doses of sucrose and xylitol respectively reveals no relevant changes of a variety of clinical parameters which would indicate any kind of metabolic intolerance to these sweetening substances.
在一项临床研究中，12名健康志愿者连续食用标准化基础饮食，并分别补充蔗糖（6天，80 - 100克/天）或木糖醇（18天，40 - 100克/天）。研究还包括正常饮食的前后阶段。除了木糖醇给药开始时出现少数腹泻病例外，没有其他临床症状表明存在与治疗相关的副作用。在木糖醇摄入期间，血浆胆固醇值有下降趋势，而甘油三酯水平未受影响。其他一些曾被认为受碳水化合物摄入影响的参数（如尿钙、草酸以及血浆尿酸）实际上并未因本研究的饮食方案而改变。各种其他血清和尿液参数在不同治疗组之间也未显示出差异。从这些数据可以得出结论，在当前实验条件下，分别亚慢性摄入相当剂量的蔗糖和木糖醇，未显示出各种临床参数有相关变化，这表明对这些甜味剂不存在任何形式的代谢不耐受。
