Rose R C, Nahrwold D L
J Natl Cancer Inst. 1982 Apr;68(4):619-22.
The specific effects of bile acids as cocarcinogens were investigated. Absorptions of [14C]7,12-dimethylbenz[a]anthracene, [14C]dimethylhydrazine ([14C]DMH), and [3H]inulin from loops of colons from outbred Sprague-Dawley rats and Hartley guinea pigs were determined. In each animal absorption of one carcinogen and inulin was studied in one control loop and in an experimental loop containing either deoxycholic acid (DOC) or chenodeoxycholic acid (CDOC). DOC had a more pronounced effect on increasing loss of carcinogen from the intestinal lumen than did CDOC. This role of bile acids was consistent with their known effect of increasing intestinal permeability. Less carcinogen remained in the colon mucosa when DOC was present in the intestinal lumen. Although [14C]DMH was absorbed more rapidly from the intestinal lumina of guinea pigs than from those of rats, the rat accumulated more of the carcinogen in the intestinal mucosa and liver.
研究了胆汁酸作为促癌剂的具体作用。测定了远交群斯普拉格-道利大鼠和哈特利豚鼠结肠肠袢对[14C]7,12-二甲基苯并[a]蒽、[14C]二甲基肼（[14C]DMH）和[3H]菊粉的吸收情况。在每只动物中，在一个对照肠袢和一个含有脱氧胆酸（DOC）或鹅脱氧胆酸（CDOC）的实验肠袢中研究一种致癌物和菊粉的吸收。与CDOC相比，DOC对增加致癌物从肠腔的损失有更明显的作用。胆汁酸的这一作用与其增加肠道通透性的已知作用一致。当肠腔中存在DOC时，结肠黏膜中残留的致癌物较少。尽管[14C]DMH从豚鼠肠腔的吸收比从大鼠肠腔的吸收更快，但大鼠在肠黏膜和肝脏中积累的致癌物更多。
