甲环亚硝脲对各种实验性淋巴网状细胞瘤的抑瘤作用。

The oncostatic effect of methyl-CCNU on various experimental lymphoreticular neoplasms.

作者信息

Peled A, Perk K, Haran-Ghera N, Chirigos M A

出版信息

Leuk Res. 1982;6(1):89-95. doi: 10.1016/0145-2126(82)90047-9.

Abstract

Studies on the chemotherapeutic potential of methyl-CCNU on experimental leukemias were undertaken. A number of murine transplantable in vivo lines (chemical carcinogen-induced T and B leukemias; radiation- and viral-induced T leukemias of C57BL/6, C3H/eb and SJL/J origin; radiation-induced myeloid leukemias and spontaneous reticulum cell neoplasms of SJL/J mine) were used in these studies. The optimal dose of methyl-CCNU and optimal timing of administration were extensively investigated on two sample lines of T cell leukemias of C57BL/6 mice. Leukemic cell eradication could be achieved in almost all of the different leukemias treated, irrespective of whether induction was brought about by chemical or physical means or due to a viral leukemogenic agent. Studies undertaken to elucidate the effect of methyl-CCNU on the establishment of preleukemic cells following induction of leukemia by the radiation leukemia virus (RadLV) or by total body irradiation, indicated the oncostatic effect of methyl-CCNU on early preleukemic cells.

摘要

开展了关于甲基环己亚硝脲对实验性白血病化疗潜力的研究。这些研究使用了多种小鼠体内可移植系（化学致癌物诱导的T和B白血病；源自C57BL/6、C3H/eb和SJL/J的辐射和病毒诱导的T白血病；辐射诱导的髓性白血病以及SJL/J品系的自发性网状细胞肿瘤）。在C57BL/6小鼠的两个T细胞白血病样本系上广泛研究了甲基环己亚硝脲的最佳剂量和最佳给药时间。几乎所有接受治疗的不同白血病，无论其诱导是通过化学或物理手段还是由于病毒致白血病因子引起，都能实现白血病细胞的清除。为阐明甲基环己亚硝脲对辐射白血病病毒（RadLV）或全身照射诱导白血病后白血病前期细胞形成的影响而进行的研究表明，甲基环己亚硝脲对早期白血病前期细胞具有抑癌作用。