Haran-Ghera N, Ben-Yaakov M, Chazan R, Peled A
Bibl Haematol. 1975(40):133-41. doi: 10.1159/000397527.
The radiation- and radiation leukemia virus-induced leukemias in C57BL/6 strain mice were found to be of the thymus-derived (T) lymphocyte origin. Experimental evidence indicated that the interaction of the radiation leukemia virus with thymus-derived lymphoid cells and specifically with the thymus subpopulation bearing high levels of H-2 alloantigens were prerequisites for the development of high leukemia incidence in these test systems. In radiation leukemogenesis in C57BL/6 mice it was shown that within several days following the radiation treatment a "released" leukemogenic agent was found in the irradiated bone marrow; whereas, several days following chemical carcinogen leukemogenesis in SJL/J mice, established preleukemic or leukemic cells could be detected in the bone marrow. The analysis concerned with the lymphoid origin of chemical carcinogen-induced lymphatic leukemias in SJL/J mice indicated clearly that the carcinogen could affect different lymphoid populations. The majority of the chemical-induced leukemias were of the bone marrow-derived (B) lymphocyte origin, although some leukemias were of T lymphocyte origin, and some tumors could not be classified as either T or B leukemias, perhaps representing stem cells which do not carry the characteristic surface antigens for mature T and B cells.
在C57BL/6品系小鼠中，辐射及辐射白血病病毒诱导产生的白血病被发现源自胸腺衍生的（T）淋巴细胞。实验证据表明，辐射白血病病毒与胸腺衍生的淋巴细胞，特别是与携带高水平H-2同种抗原的胸腺亚群之间的相互作用，是这些测试系统中白血病高发病率发展的先决条件。在C57BL/6小鼠的辐射白血病发生过程中，研究表明在辐射治疗后的几天内，在受辐射的骨髓中发现了一种“释放”的致白血病因子；而在SJL/J小鼠化学致癌物诱导白血病发生后的几天里，可在骨髓中检测到已形成的白血病前期或白血病细胞。对SJL/J小鼠化学致癌物诱导的淋巴白血病的淋巴细胞起源分析清楚地表明，致癌物可影响不同的淋巴细胞群体。大多数化学诱导的白血病源自骨髓衍生的（B）淋巴细胞，尽管有些白血病源自T淋巴细胞，还有一些肿瘤无法归类为T或B白血病，可能代表不携带成熟T和B细胞特征性表面抗原的干细胞。
