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喂食鱼油可降低大鼠血小板和主动脉中血栓素和前列环素的生成，且不会导致前列腺素I3的形成。

Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3.

作者信息

Hornstra G, Christ-Hazelhof E, Haddeman E, ten Hoor F, Nugteren D H

出版信息

Prostaglandins. 1981 May;21(5):727-38. doi: 10.1016/0090-6980(81)90230-6.

DOI:10.1016/0090-6980(81)90230-6
PMID:6803303
Abstract

It is demonstrated that feeding cod-liver oil to rats leads to a considerable reduction in the formation of platelet TxA2 and of vascular PGI2. No appreciable formation of TxA3 and PGI3 is observed, although arterial thrombosis is depressed and bleeding time is prolonged. These findings contradict the suggested role of prostaglandins of the 3-series in thromboregulation.

摘要

结果表明，给大鼠喂食鱼肝油会导致血小板血栓素A2（TxA2）和血管前列环素（PGI2）的生成显著减少。尽管动脉血栓形成受到抑制且出血时间延长，但未观察到血栓素A3（TxA3）和前列环素I3（PGI3）的明显生成。这些发现与所提出的3 - 系列前列腺素在血栓调节中的作用相矛盾。

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1
Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3.喂食鱼油可降低大鼠血小板和主动脉中血栓素和前列环素的生成，且不会导致前列腺素I3的形成。
Prostaglandins. 1981 May;21(5):727-38. doi: 10.1016/0090-6980(81)90230-6.
2
Thromboxane A2 and prostacyclin formation in rats fed cod-liver or sunflower oil.喂食鳕鱼肝油或葵花籽油的大鼠体内血栓素A2和前列环素的生成
Nutr Rev. 1982 May;40(5):157-9. doi: 10.1111/j.1753-4887.1982.tb05296.x.
3
Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat.作为含玉米油饮食的补充剂给予鱼油，对大鼠动脉前列环素生成的影响大于对血小板血栓素生成的影响。
Prostaglandins. 1983 May;25(5):693-710. doi: 10.1016/0090-6980(83)90123-5.
4
Modulation of Platelet thromboxane A2 and arterial prostacyclin by dietary vitamin E.膳食维生素E对血小板血栓素A2和动脉前列环素的调节作用。
Prostaglandins. 1981 Oct;22(4):651-61. doi: 10.1016/0090-6980(81)90074-5.
5
Aspirin, thromboxane, and prostacyclin in rats: A dilemma resolved?大鼠体内的阿司匹林、血栓素和前列环素：困境得到解决了吗？
Lancet. 1978 Jun 17;1(8077):1307. doi: 10.1016/s0140-6736(78)91286-2.
6
In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis.动脉粥样硬化患者服用鱼油期间血小板和血管功能的体内指标。
N Engl J Med. 1986 Apr 10;314(15):937-42. doi: 10.1056/NEJM198604103141501.
7
[The modification of the biosynthesis and effect of thromboxane A2 and prostacyclin by trapidil (Rocornal)].曲匹地尔（心可定）对血栓素A2和前列环素生物合成及作用的影响
Biomed Biochim Acta. 1983;42(2-3):283-99.
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Dietary manipulation of prostaglandin and thromboxane synthesis in heart, aorta and blood platelets of the rat.大鼠心脏、主动脉和血小板中前列腺素和血栓素合成的饮食调控
Adv Prostaglandin Thromboxane Res. 1980;8:1771-81.
9
Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat.在大鼠中，给予鱼油对前列环素生成和主动脉壁抗聚集活性的降低作用，比对血小板聚集和血栓素的降低作用更有效。
Adv Prostaglandin Thromboxane Leukot Res. 1983;12:185-91.
10
[Determination of TXA2 formed by blood platelets and PGX formed by blood vessels and formation of thrombi].[血小板生成的血栓素A2及血管生成的前列环素的测定与血栓形成]
Ugeskr Laeger. 1977 Nov 21;139(47):2815-6.

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