De Backer G, Rosseneu M, Deslypere J P
Atherosclerosis. 1982 Apr;42(2-3):197-203. doi: 10.1016/0021-9150(82)90150-2.
Serum cholesterol, HDL cholesterol (HDL-C), and apoproteins, A1, A2 and B were determined in 70 male survivors of myocardial infarction and in an equal number of healthy controls, matched for age, sex and body mass index. In univariate analyses, the Apo B/Apo A1 ratio discriminated the best between cases and controls, giving a 72% exact classification. In a multivariate analysis, the Apo B/Apo A1 ratio, HDL-C and the Apo A2/Apo A1 ratio contributed independently to the discrimination of cases from controls while the overall exact classification was 82%. These promising results were comparable in younger and older subgroups. Thus, the determination of apoproteins yielded complementary information in this cross-sectional survey and warrants further study in a prospective setting.
对70名心肌梗死男性幸存者以及数量相同、年龄、性别和体重指数相匹配的健康对照者测定了血清胆固醇、高密度脂蛋白胆固醇（HDL-C）以及载脂蛋白A1、A2和B。在单变量分析中，载脂蛋白B/载脂蛋白A1比值在病例组和对照组之间的区分效果最佳，精确分类率为72%。在多变量分析中，载脂蛋白B/载脂蛋白A1比值、HDL-C以及载脂蛋白A2/载脂蛋白A1比值对病例组和对照组的区分均有独立贡献，而总体精确分类率为82%。这些有前景的结果在年轻和老年亚组中具有可比性。因此，在这项横断面调查中，载脂蛋白的测定产生了补充信息，值得在前瞻性研究中进一步探讨。
