De Backer G, Hulstaert F, De Munck K, Rosseneu M, Van Parijs L, Dramaix M
Am Heart J. 1986 Sep;112(3):478-84. doi: 10.1016/0002-8703(86)90510-7.
Lipids and apoproteins as well as other coronary risk factors were measured in offspring of patients who suffered from a myocardial infarction before the age of 50 years; the results are compared with the results of a control group matched for age and sex. Significant differences were observed in the apoprotein A1 level, in the protein/fat ratios of high- and low-density lipoproteins, and in smoking habits. In a multivariate analysis, the offspring group was found to be different from the control group in nonhigh-density lipoprotein cholesterol/apoprotein B ratio, high-density lipoprotein cholesterol/apoprotein A1 ratio, smoking habits, apoprotein A1, and apoprotein A2. By means of these variables a total of 85% of all subjects could be correctly classified. We conclude that as early as age 21 years the offspring of patients with premature coronary heart disease differ from matched control subjects in lipoprotein measurements and in smoking habits.
对50岁之前发生过心肌梗死的患者的后代进行了脂质、载脂蛋白以及其他冠心病风险因素的测量；并将结果与年龄和性别相匹配的对照组的结果进行了比较。观察到载脂蛋白A1水平、高密度和低密度脂蛋白的蛋白质/脂肪比率以及吸烟习惯存在显著差异。在多变量分析中，发现后代组在非高密度脂蛋白胆固醇/载脂蛋白B比率、高密度脂蛋白胆固醇/载脂蛋白A1比率、吸烟习惯、载脂蛋白A1和载脂蛋白A2方面与对照组不同。通过这些变量，所有受试者中有85%能够被正确分类。我们得出结论，早在21岁时，早发性冠心病患者的后代在脂蛋白测量和吸烟习惯方面就与匹配的对照受试者有所不同。
