Kligman A M, Kaidbey K H
Eur J Rheumatol Inflamm. 1982;5(2):124-37.
Photosensitization to benoxaprofen has been studied in human volunteers. The wavelengths that mediate the reaction lie mainly just outside the sunburn range in the near ultraviolet, UVA region including, however the terminal portion of the UVB region. The photosensitivity reaction begins with sharp burning during exposure, sometimes accompanied by itching. This may be followed by erythema and a flare, which generally fade in about one hour or less. High doses of ultraviolet light can elicit whealing. Photosensitivity to benoxaprofen is typically an immediate-type, short-lived reaction, dominated by subjective sensations of burning-smarting and redness. With large UVA doses, a sunburn-type reaction may also be present at 24 hours. The photosensitivity is of the phototoxic type. It may appear within 48 hours of starting the drug and usually disappears with 48 hours after stopping. The population most at risk are type 1 and type 2 light-skinned persons who burn easily and tan poorly. Pigmented races are quite resistant, viz, blacks and orientals. Dark-skinned type 4 Caucasoids, such as Mexicans, Indians, etc., have high innate protection. Deep tanning and SPF 15 sunscreens provide adequate protection.
已在人类志愿者中研究了对苯恶洛芬的光敏反应。介导该反应的波长主要位于晒伤范围之外的近紫外线UVA区域，但也包括UVB区域的末端部分。光敏反应在暴露期间以剧烈灼痛开始，有时伴有瘙痒。随后可能出现红斑和潮红，通常在约一小时或更短时间内消退。高剂量紫外线可引起风团。对苯恶洛芬的光敏性通常是一种即时型、短暂的反应，主要表现为灼痛-刺痛和发红的主观感觉。大剂量UVA照射后，24小时也可能出现晒伤型反应。这种光敏性属于光毒性类型。它可能在开始用药后48小时内出现，通常在停药后48小时内消失。最易受影响的人群是1型和2型皮肤白皙、容易晒伤且不易晒黑的人。有色人种，即黑人和东方人，对此相当耐受。深色皮肤的4型白种人，如墨西哥人、印度人等，具有较高的先天保护能力。深度晒黑和SPF 15的防晒霜可提供足够的保护。
