免疫球蛋白同种异型与对A群和C群脑膜炎球菌多糖的免疫反应。

Immunoglobulin allotypes and immune response to meningococcal polysaccharides A and C.

作者信息

Pandey J P, Ambrosch F, Fudenberg H H, Stanek G, Wiedermann G

出版信息

J Immunogenet. 1982 Feb;9(1):25-9. doi: 10.1111/j.1744-313x.1982.tb00779.x.

DOI:10.1111/j.1744-313x.1982.tb00779.x

Abstract

Serum samples were collected from 113 healthy Caucasian volunteers before and after vaccination with meningococcal polysaccharides (MPS) group A and group C. Antibodies to MPS group A and group C were measured and sera were typed for several Gm and Km(1) allotypes. A significant association was found between the Gm 1,3,17; 5,13,14,21 phenotype and low immune responsiveness to MPS group A. These results suggest the possible existence of an immunoglobulin allotype-linked immune suppression (Is) gene(s) in man.

摘要

从113名健康的高加索志愿者身上采集血清样本，这些志愿者在接种A群和C群脑膜炎球菌多糖（MPS）疫苗之前和之后均被采样。检测了针对A群和C群MPS的抗体，并对血清进行了几种Gm和Km(1) 同种异型分型。发现Gm 1,3,17; 5,13,14,21表型与对A群MPS的低免疫反应性之间存在显著关联。这些结果表明，人类中可能存在免疫球蛋白同种异型相关的免疫抑制（Is）基因。