Michelsen C B, Askanazi J, Kinney J M, Gump F E, Elwyn D H
J Trauma. 1982 May;22(5):410-3. doi: 10.1097/00005373-198205000-00011.
The effect of an anabolic steroid, nandrolone decanoate, on nitrogen balance and plasma and muscle amino acid concentrations was studied in patients undergoing total hip replacement and receiving daily postoperative infusions of 5% dextrose and 3.5% amino acids. An intramuscular injection of 200 mg immediately after operation resulted in a nitrogen balance of -48 mg N/kg . day for the first 3 days, as compared to 102 mg N/kg . day in noninjected controls. After steroid injection there was also an attenuation of trauma-induced changes in amino acid concentrations in muscle but not in plasma. This suggests that nandrolone decanoate may act directly on muscle to reduce the protein catabolism which follows a major form of operative trauma.
在接受全髋关节置换术且术后每日输注5%葡萄糖和3.5%氨基酸的患者中，研究了合成代谢类固醇癸酸诺龙对氮平衡以及血浆和肌肉氨基酸浓度的影响。术后立即肌肉注射200毫克，前3天氮平衡为-48毫克氮/千克·天，而未注射的对照组为102毫克氮/千克·天。注射类固醇后，创伤引起的肌肉中氨基酸浓度变化有所减弱，但血浆中没有。这表明癸酸诺龙可能直接作用于肌肉，以减少重大手术创伤后随之而来的蛋白质分解代谢。
