Young G A, Yule A G, Hill G L
JPEN J Parenter Enteral Nutr. 1983 May-Jun;7(3):221-5. doi: 10.1177/0148607183007003221.
In this controlled trial we have studied the effect of anabolic steroid on ill surgical patients receiving intravenous hyperalimentation. Body composition, plasma proteins, and amino acids were compared in each of two groups of 12 patients before and after 14 days of intravenous feeding. The patients in one group were given 100 mg of nandrolone decanoate at the commencement of study and again one week later. Body weight, muscle (AMC), plasma transferrin, prealbumin, and retinol-binding protein were increased comparably in both groups. An apparent gain in total body nitrogen was not significant. However, anabolic steroid caused greater gain of water requiring a more liberal use of diuretics, but prevented the gains of fat, triglyceride and insulin that occurred in the control group. Most plasma amino acids increased due to intravenous hyperalimentation but decreased in patients given anabolic steroid. It is concluded that in patients who may be in the catabolic phase of recovery anabolic steroid probably enhances amino acid and water uptake by tissues and increases the utilization of fat but, does not promote any greater increase in "visceral" proteins than during intravenous hyperalimentation alone.
在这项对照试验中，我们研究了合成代谢类固醇对接受静脉高营养的外科手术患者的影响。在两组各12名患者进行14天静脉喂养前后，对其身体成分、血浆蛋白和氨基酸进行了比较。一组患者在研究开始时给予100mg癸酸诺龙，一周后再次给药。两组患者的体重、肌肉（上臂中部周长）、血浆转铁蛋白、前白蛋白和视黄醇结合蛋白均有相当程度的增加。总体氮的明显增加并不显著。然而，合成代谢类固醇导致水分增加更多，需要更大量使用利尿剂，但可防止对照组出现的脂肪、甘油三酯和胰岛素增加。大多数血浆氨基酸因静脉高营养而增加，但在使用合成代谢类固醇的患者中减少。得出的结论是，对于可能处于恢复分解代谢阶段的患者，合成代谢类固醇可能会增强组织对氨基酸和水的摄取，并增加脂肪的利用，但与仅进行静脉高营养相比，并不会促使“内脏”蛋白有更大增加。
