特发性血色素沉着症中血清铁蛋白与全身铁储存的关系。
Relationship between serum ferritin and total body iron stores in idiopathic haemochromatosis.
作者信息
Powell L W, Halliday J W, Cowlishaw J L
出版信息
Gut. 1978 Jun;19(6):538-42. doi: 10.1136/gut.19.6.538.
The relationship between the serum ferritin concentration and total body iron stores was investigated in 41 patients with idiopathic haemochromatosis and 199 first or second degree relatives. Thirty-two relatives (16.1%) had increased iron stores and serum ferritin levels were increased in all but one of them. The false-positive rate in the relatives with normal iron stores was 1.8% compared with 10% for the serum iron concentration and 33% for the transferrin saturation. There was a significant correlation between the serum ferritin concentration and both the chelatable body iron and the hepatic iron concentration. We conclude that in the natural history of classical idiopathic haemochromatosis the serum ferritin concentration is usually raised when hepatic iron stores are increased and before there is architectural damage to the liver.
对41例特发性血色素沉着症患者及199名一级或二级亲属的血清铁蛋白浓度与机体总铁储存之间的关系进行了研究。32名亲属（16.1%）铁储存增加，除1人外其余所有人的血清铁蛋白水平均升高。铁储存正常的亲属中假阳性率为1.8%，而血清铁浓度的假阳性率为10%，转铁蛋白饱和度的假阳性率为33%。血清铁蛋白浓度与可螯合机体铁及肝脏铁浓度之间存在显著相关性。我们得出结论，在经典型特发性血色素沉着症的自然病程中，当肝脏铁储存增加且肝脏尚未出现结构损伤时，血清铁蛋白浓度通常会升高。
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