Chapman R W, Gorman A, Laulicht M, Hussain M A, Sherlock S, Hoffbrand A V
J Clin Pathol. 1982 May;35(5):481-6. doi: 10.1136/jcp.35.5.481.
Total serum ferritin and the proportion of serum ferritin binding to concanavalin A (glycosylated ferritin) was measured in 18 healthy volunteers and in 84 patients, eight with primary haemochromatosis, 43 with beta-thalassaemia major and secondary iron overload and 33 with chronic liver diseases without iron overload. The total serum ferritin was either equally or even more closely related than either the non-binding or the concanavalin A binding ferritin, to the liver iron concentration in all patients with iron overload, and with the units of blood transfused in non-chelated thalassaemic patients. The total serum ferritin showed a significant correlation with serum aminotransferase for the group of 84 patients. In the thalassaemic patients the ferritin binding to concanavalin A also correlated with aminotransferase. However, in the other groups it was the ferritin not binding to concanavalin A which showed a significant correlation with aminotransferase activity. These results suggest that measuring the fraction of serum ferritin which binds to concanavalin A does not offer any advantage over estimation of the total serum ferritin concentration in the assessment of iron stores in patients wit iron overload and liver damage.
在18名健康志愿者和84名患者中测量了血清总铁蛋白以及与伴刀豆球蛋白A结合的血清铁蛋白比例（糖基化铁蛋白），其中8名患有原发性血色素沉着症，43名患有重型β地中海贫血和继发性铁过载，33名患有无铁过载的慢性肝病。在所有铁过载患者中，血清总铁蛋白与肝脏铁浓度的相关性与未结合或与伴刀豆球蛋白A结合的铁蛋白相同甚至更紧密，并且与未进行螯合治疗的地中海贫血患者的输血单位数相关。在这84名患者中，血清总铁蛋白与血清转氨酶呈显著相关。在地中海贫血患者中，与伴刀豆球蛋白A结合的铁蛋白也与转氨酶相关。然而，在其他组中，与伴刀豆球蛋白A不结合的铁蛋白与转氨酶活性呈显著相关。这些结果表明，在评估铁过载和肝脏损伤患者的铁储备时，测量与伴刀豆球蛋白A结合的血清铁蛋白比例相较于估计血清总铁蛋白浓度并无优势。
