正常受试者和特发性血色素沉着症患者的铁吸收：与血清铁蛋白浓度的关系。
Iron absorption in normal subjects and patients with idiopathic haemochromatosis: relationship with serum ferritin concentration.
作者信息
Walters G O, Jacobs A, Worwood M, Trevett D, Thomson W
出版信息
Gut. 1975 Mar;16(3):188-92. doi: 10.1136/gut.16.3.188.
Abstract
In 52 normal subjects there was an inverse relationship between serum ferritin concentration and iron absorption. In 21 measurements in 15 patients with idiopathic haemochromatosis there was a similar inverse relationship but absorption was higher in relation to iron stores at all levels. Haemochromatotic patients with normal serum ferritin levels had abnormally high values for desferrioxamine chelatable iron and there was no correlation between chelatable iron and iron absorption.
摘要
在52名正常受试者中，血清铁蛋白浓度与铁吸收之间呈负相关。在15例特发性血色素沉着症患者的21次测量中，也存在类似的负相关，但在所有水平上，相对于铁储存量而言，吸收都更高。血清铁蛋白水平正常的血色素沉着症患者去铁胺可螯合铁的值异常高，且可螯合铁与铁吸收之间无相关性。
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本文引用的文献
1
METHOD FOR THE AUTOMATIC DETERMINATION OF SERUM IRON.血清铁自动测定方法
J Clin Pathol. 1965 Jan;18(1):98-102. doi: 10.1136/jcp.18.1.98.
2
DIFFERENTIAL FERRIOXAMINE TEST FOR MEASURING CHELATABLE BODY IRON.用于测量可螯合体内铁的去铁胺差异试验。
J Clin Pathol. 1965 Jan;18(1):88-97. doi: 10.1136/jcp.18.1.88.
3
THE SIGNIFICANCE OF IRON TURNOVER IN THE CONTROL OF IRON ABSORPTION.铁周转在铁吸收控制中的意义
Blood. 1964 Jul;24:19-24.
4
THE CONTROL OF IRON BALANCE BY THE INTESTINAL MUCOSA.肠道黏膜对铁平衡的调控
Blood. 1963 Oct;22:441-9.
5
The natural history of iron deficiency induced by phlebotomy.放血疗法所致缺铁的自然病程。
Blood. 1962 Aug;20:173-85.
6
Iron absorption. I. Factors influencing absorption.铁的吸收。一、影响吸收的因素。
J Lab Clin Med. 1958 Jan;51(1):24-36.
7
Humoral regulation of iron absorption.
Gastroenterology. 1969 Aug;57(2):225-8.
8
The chelation of iron during intestinal absorption.肠道吸收过程中铁的螯合作用。
J Lab Clin Med. 1969 Aug;74(2):212-7.
9
Some factors affecting the release of iron from reticuloendothelial cells.一些影响网状内皮细胞铁释放的因素。
Br J Haematol. 1971 Sep;21(3):289-303. doi: 10.1111/j.1365-2141.1971.tb03441.x.
10
Iron absorption in idiopathic haemochromatosis and its measurement using a whole-body counter.
Clin Sci. 1969 Oct;37(2):519-31.
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