人类大肠黏膜中的唾液酸：正常和恶性状态下的O-酰化变体
Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states.
作者信息
Rogers C M, Cooke K B, Filipe M I
出版信息
Gut. 1978 Jul;19(7):587-92. doi: 10.1136/gut.19.7.587.
Abstract
Five sialic acid variants have been demonstrated in normal, 'transitional', and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic acids with additional O-acylation. Cases studied so far show changes in the proportions of these variants in malignancy.
摘要
通过薄层色谱法已在人大肠黏膜的正常、“过渡性”及肿瘤提取物中证实了五种唾液酸变体。采用中间碱性水解的二维薄层色谱法证实这些变体为具有额外O-酰化作用的N-乙酰神经氨酸。目前所研究的病例显示出这些变体在恶性肿瘤中的比例变化。
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