Massarrat S, Heuser E, Hausmann L, Schubotz R
Dtsch Med Wochenschr. 1982 Jul 16;107(28):1085-8. doi: 10.1055/s-2008-1070078.
The long term effect of 400 mg cimetidine ingested at various times on ulcer recurrence and drug compliance was investigated in 66 patients with severe course of duodenal ulcer, now healed. Patients were randomised in 3 treatment groups: group A (n = 29) received 400 mg cimetidine in the evening, group B (n = 23) 200 mg both morning and evening, group C (n = 14) no treatment. Follow up examinations were at 3 month intervals. Ulcer recurrence was observed in 10 out of 14 patients in group C and in 12 out of 52 patients of groups A and B within the first 6 months. Due to the highly significant difference between the treated and untreated groups (P less than 0.001) the control group was discontinued. The recurrence rate after 12 months was identical in groups A and B (51 and 52%). Comparison of patients with and without recurrences showed no differences as regards length of history, maximal acid secretion, cimetidine compliance or endoscopic findings such as duodenitis, circular constriction of the bulbus or antral erosions. However, it was noticeable that smokers with 63% recurrent ulceration had a worse prognosis than the non-smokers with 37% (P = 0.06).
对66例十二指肠溃疡病情严重但现已愈合的患者，研究了在不同时间服用400毫克西咪替丁对溃疡复发和药物依从性的长期影响。患者被随机分为3个治疗组：A组（n = 29）在晚上服用400毫克西咪替丁，B组（n = 23）早晚各服用200毫克，C组（n = 14）不进行治疗。随访检查每隔3个月进行一次。在最初6个月内，C组14例患者中有10例出现溃疡复发，A组和B组52例患者中有12例出现溃疡复发。由于治疗组和未治疗组之间存在高度显著差异（P小于0.001），对照组停止治疗。12个月后A组和B组的复发率相同（分别为51%和52%）。对有复发和无复发的患者进行比较，结果显示在病史长短、最大胃酸分泌、西咪替丁依从性或内镜检查结果（如十二指肠炎、球部环形狭窄或胃窦糜烂）方面均无差异。然而，值得注意的是，溃疡复发率为63%的吸烟者预后比溃疡复发率为37%的非吸烟者更差（P = 0.06）。
