Massarrat S, Enschai F, Pittner P M
Gut. 1986 Apr;27(4):433-9. doi: 10.1136/gut.27.4.433.
The relationship between smoking and gastric secretory capacity was studied in 201 25-40 year old healthy subjects with normal laboratory data and no gastrointestinal lesions. Basal acid output (BAO) and peak acid output (PAO) were determined in all, and basal and stimulated pepsin outputs were measured in 85 participants. The accuracy of the patients' statements was checked by urinary nicotine assay. Basal acid output and PAO were significantly higher in male smokers (n = 55) than in male non-smokers (n = 49). In women PAO in smokers (n = 38) was higher than in non-smokers (n = 59). Female smokers (n = 38) had a higher pepsin output than female non-smokers (n = 23). Eight variables were considered in relation to BAO and PAO: age, height, weight, alcohol abuse, smoking habits, duration of smoking habit, number of cigarettes per day, and the product of years of smoking multiplied by daily number of cigarettes. The daily number of cigarettes X years of smoking was most closely correlated with BAO and PAO by stepwise multiple linear regression analysis. It was concluded that smoking is related to increased gastric acid capacity.
在201名年龄在25至40岁之间、实验室数据正常且无胃肠道病变的健康受试者中，研究了吸烟与胃分泌能力之间的关系。测定了所有人的基础胃酸分泌量（BAO）和最大胃酸分泌量（PAO），并对85名参与者测量了基础和刺激后的胃蛋白酶分泌量。通过尿尼古丁检测来检验患者陈述的准确性。男性吸烟者（n = 55）的基础胃酸分泌量和最大胃酸分泌量显著高于男性非吸烟者（n = 49）。在女性中，吸烟者（n = 38）的最大胃酸分泌量高于非吸烟者（n = 59）。女性吸烟者（n = 38）的胃蛋白酶分泌量高于女性非吸烟者（n = 23）。考虑了与基础胃酸分泌量和最大胃酸分泌量相关的八个变量：年龄、身高、体重、酗酒、吸烟习惯、吸烟习惯持续时间、每日吸烟量以及吸烟年数乘以每日吸烟量的乘积。通过逐步多元线性回归分析，每日吸烟量×吸烟年数与基础胃酸分泌量和最大胃酸分泌量的相关性最为密切。得出的结论是，吸烟与胃酸分泌能力增加有关。
